56 KDA type-specific antigen 蛋白, Orientia tsutsugamushi (Cell-Free, His)

56 KDA type‐specific antigenic proteins have dual roles as key adhesion factors for adsorption of rickettsiae to host cell surfaces and as determinants of the virulence of individual rickettsial strains. As a major outer membrane protein, it occupies a central position in the interaction between pathogens and host cells. 56 KDA type-specific antigen Protein, Orientia tsutsugamushi (Cell-Free, His) is the recombinant 56 KDA type-specific antigen protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of 56 KDA type-specific antigen Protein, Orientia tsutsugamushi (Cell-Free, His) is 499 a.a., with molecular weight of 57 kDa.

56 KDA 型特异性抗原蛋白似乎具有双重作用，既是立克次体吸附到宿主细胞表面的关键粘附因子，又是单个立克次体菌株毒力的决定因素。它的重要性在于它是主要的外膜蛋白，表明在病原体和宿主细胞之间的相互作用中处于中心位置。作为一种粘附因子，该蛋白质可能通过促进立克次体颗粒与宿主细胞的结合而在感染的初始阶段发挥关键作用。此外，它在确定特定立克次体菌株毒力方面的作用强调了它对与这些细菌制剂相关的致病性和感染结果的潜在影响。阐明 56 KDA 型特异性抗原促进立克次体粘附和毒力的精确机制可以增强我们对宿主-病原体相互作用的理解，并为制定靶向治疗策略提供见解。

Others

E. coli Cell-free

N-10*His

P37917 (I23-F521)

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IEFDENSLECGPYAKVGIVGGVLSGVESARLDPADSEGKKHLPLIKGMPFGVTLAAGMTITPGVRAEISAMYLMNVKAEVELGKMGSDANTGTTADASAGVIRKHKKLTPPQPNIMPISIADRDIAVDIPNAAGQGNVDVRAAARIAWLKNYAGIDYYVPDSNNPQGRVVNPVLLNIPQGNPNPAGGGGRAAPAAFDILDHAQWRDVVVGITALSNANKPNVSAVKILSDKISQIYADIKPFANVASVQISETPLPDSASVDQIQNKVQELNKVLEDVRESFDGFILNAFAQPVRLNFQIPQVVQGQGQQPQAAATAQEAAAAAAIRALNDGENNGIIQLYKDLYKLQRNVALKKSMKQLGDELGVDQGQEGGCSKDKKQSDTTAEESKKEGKKGKEIEFDLHMAVGQVKLYADLFTIDSFSVYAGIGAGLAYTHGKIDGKDIKAHTGMVGSLALGVAANVADGVYMDVDAGYLYSFSKIEEKYQMNAFVASAGIRYNF

57 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.