ADIPOR1 蛋白, Human (Cell-Free, His, SUMO, Myc)

ADIPOR1 Protein, a receptor for adiponectin (ADIPOQ), crucially regulates glucose and lipid metabolism, maintaining homeostasis and healthy body weight. Upon ADIPOQ binding, ADIPOR1 activates AMPK, promoting fatty acid oxidation and glucose uptake while inhibiting gluconeogenesis. ADIPOR1 interacts with APPL2, negatively regulating signaling, and with APPL1, enhancing ADIPOQ-induced recruitment and positive regulation of adiponectin signaling. ADIPOR1 Protein, Human (Cell-Free, His, SUMO, Myc) is the recombinant human-derived ADIPOR1 protein, expressed by E. coli Cell-free , with N-10*His, C-Myc, N-SUMO labeled tag. The total length of ADIPOR1 Protein, Human (Cell-Free, His, SUMO, Myc) is 375 a.a., with molecular weight of 62.6 kDa.

ADIPOR1 蛋白充当脂联素 (ADIPOQ) 的受体，脂联素是脂肪细胞分泌的一种重要激素，在调节葡萄糖和脂质代谢中发挥着至关重要的作用。它的功能对于维持正常的葡萄糖和脂肪稳态以及健康的体重至关重要。与 ADIPOQ 结合后，ADIPOR1 激活信号级联，导致 AMP 激活蛋白激酶 (AMPK) 活性增加，从而增强脂肪酸氧化、增加葡萄糖摄取并减少糖异生。ADIPOR1 对球状脂联素表现出高亲和力，对全长脂联素表现出较低的亲和力。它可以与ADIPOR2形成同源寡聚物和异源寡聚物。与 APPL2 的相互作用负向调节脂联素信号传导，而 ADIPOQ 增强与 APPL1 的相互作用，促进 APPL1 募集到 ADIPOR1 并正向调节脂联素信号传导。

Human

E. coli Cell-free

N-10*His;C-Myc;N-SUMO

Q96A54 (M1-L375)

51094

MSSHKGSVVAQGNGAPASNREADTVELAELGPLLEEKGKRVIANPPKAEEEQTCPVPQEEEEEVRVLTLPLQAHHAMEKMEEFVYKVWEGRWRVIPYDVLPDWLKDNDYLLHGHRPPMPSFRACFKSIFRIHTETGNIWTHLLGFVLFLFLGILTMLRPNMYFMAPLQEKVVFGMFFLGAVLCLSFSWLFHTVYCHSEKVSRTFSKLDYSGIALLIMGSFVPWLYYSFYCSPQPRLIYLSIVCVLGISAIIVAQWDRFATPKHRQTRAGVFLGLGLSGVVPTMHFTIAEGFVKATTVGQMGWFFLMAVMYITGAGLYAARIPERFFPGKFDIWFQSHQIFHVLVVAAAFVHFYGVSNLQEFRYGLEGGCTDDTLL

62.6 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.