ADRB1 蛋白, Mouse (Cell-Free, His, SUMO)

The ADRB1 protein is a beta-adrenergic receptor that critically mediates catecholamine-induced adenylyl cyclase activation through G-protein action. It has the same affinity for epinephrine and norepinephrine and responds to endogenous catecholamines. ADRB1 Protein, Mouse (Cell-Free, His, SUMO) is the recombinant mouse-derived ADRB1 protein, expressed by E. coli Cell-free , with N-6*His, N-SUMO labeled tag. The total length of ADRB1 Protein, Mouse (Cell-Free, His, SUMO) is 466 a.a., with molecular weight of 63.4 kDa.

ADRB1 蛋白是 β-肾上腺素能受体家族的成员，通过 G 蛋白作用介导儿茶酚胺诱导的腺苷酸环化酶激活，发挥着至关重要的作用。值得注意的是，该受体对肾上腺素和去甲肾上腺素表现出大致相同的亲和力，突出了其对两种内源性儿茶酚胺的反应性。ADRB1 通过 G(s)-α 和 cAMP 介导的信号传导参与 Ras 激活。此外，它参与睡眠/觉醒行为的调节强调了其更广泛的生理意义。该蛋白通过其 C 端 PDZ 基序直接与 RAPGEF2 相互作用，并显示出与 GOPC、MAGI3 和 DLG4 的关联，进一步促进 ADRB1 信号传导的复杂调节及其在多种细胞过程中的潜在作用。

Mouse

E. coli Cell-free

N-6*His;N-SUMO

P34971 (M1-V466)

11554

MGAGALALGASEPCNLSSAAPLPDGAATAARLLVLASPPASLLPPASEGSAPLSQQWTAGMGLLLALIVLLIVVGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARALVCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPEPSPSPGPPRPADSLANGRSSKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRDLVPDRLFVFFNWLGYANSAFNPIIYCRSPDFRKAFQRLLCCARRAACRRRAAHGDRPRASGCLARAGPPPSPGAPSDDDDDDAGTTPPARLLEPWTGCNGGTTTVDSDSSLDEPGRQGFSSESKV

63.4 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.