Animal-Free IL-4 蛋白, Pig (His)

IL-4 protein actively engages in B-cell activation processes and various cell types, acting as a DNA synthesis costimulator. It induces class II MHC molecule expression on resting B-cells and enhances IgE and IgG1 secretion and cell surface expression. Moreover, IL-4 regulates CD23 expression on lymphocytes and monocytes, positively impacting IL31RA expression in macrophages. Additionally, it induces autophagy in dendritic cells by interfering with mTORC1 signaling and inducing RUFY4. Animal-Free IL-4 Protein, Pig (His) is the recombinant pig-derived animal-FreeIL-4 protein, expressed by E. coli, with C-His labeled tag. The total length of Animal-Free IL-4 Protein, Pig (His) is 109 a.a., with molecular weight of ~13.5 kDa.

IL-4 蛋白积极参与多种 B 细胞激活过程和各种细胞类型，作为 DNA 合成的共刺激剂。它诱导静息 B 细胞上 II 类 MHC 分子的表达，增强 IgE 和 IgG1 的分泌和细胞表面表达，并调节淋巴细胞和单核细胞上 IgE 低亲和力 Fc 受体 (CD23) 的表达。此外，IL-4 正向调节巨噬细胞中 IL31RA 的表达，并通过干扰 mTORC1 信号传导和诱导 RUFY4 刺激树突状细胞中的自噬。

Pig

E. coli

C-His

Q04745 (H25-C133)

397225  [NCBI]

MHKCDITLQEIIKTLNILTARKNSCMELPVTDVFAAPENTTEKETFCRASTVLRHIYRHHTCMKSLLSGLDRNLSSMANMTCSVHEAKKSTLKDFLERLKTIMKEKYSKC

Approximately 13.5 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<0.1 EU per 1 μg of the protein by the LAL method.