Apolipoprotein B-100/APOB 蛋白, Human (His)

Apolipoprotein B-100 (APOB) is a critical component in chylomicrons, LDL, and VLDL. It acts as a recognition signal, facilitating cellular binding and internalization of LDL through the apoB/E receptor. APOB-100 interacts with partners like PCSK9, MTTP, AUP1, and CIDEB, influencing diverse physiological processes. The interaction with PCSK9 has implications in lipid metabolism, while associations with MTTP, AUP1, and CIDEB suggest APOB's involvement in lipid transport, metabolism, and potentially other cellular functions. Apolipoprotein B-100/APOB Protein, Human (His) is the recombinant human-derived Apolipoprotein B-100/APOB protein, expressed by E. coli, with N-6*His labeled tag. The total length of Apolipoprotein B-100/APOB Protein, Human (His) is 100 a.a., with molecular weight of ~16.0 kDa.

载脂蛋白 B-100 (APOB) 是乳糜微粒 (apo B-48)、LDL (apo B-100) 和 VLDL (apo B-100) 中的重要蛋白质成分。APOB-100 作为识别信号发挥着关键作用，通过 apoB/E 受体促进 LDL 颗粒的细胞结合和内化。该蛋白质与各种伙伴相互作用，包括 PCSK9、MTTP、AUP1 和 CIDEB，有助于不同的生理过程。例如，与 PCSK9 的相互作用对脂质代谢具有影响。此外，与 MTTP、AUP1 和 CIDEB 的关联表明 APOB 参与脂质转运、代谢和潜在的其他细胞功能。

Human

E. coli

N-6*His

P04114 (E28-S127)

338  [NCBI]

HHHHHHEEEMLENVSLVCPKDATRFKHLRKYTYNYEAESSSGVPGTADSRSATRINCKVELEVPQLCSFILKTSQCTLKEVYGFNPEGKALLKKTKNSEEFAAAMS

Approximately 16.0 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method