B2M/Beta-2 microglobulin 蛋白, Rat (119a.a, HEK293, C-His)

Beta-2 microglobulin protein (B2M) is crucial in presenting antigens, aiding immune surveillance. B2M forms a complex with an alpha chain, creating MHC class I molecules for antigen recognition. It also participates in a heterotrimer with MR1, expanding its role in antigen presentation and immune signaling pathways. B2M's intricate interactions underscore its significance in orchestrating immune responses. B2M/Beta-2 microglobulin Protein, Rat (119a.a, HEK293, C-His) is the recombinant rat-derived B2M/Beta-2 microglobulin protein, expressed by HEK293 , with C-6*His labeled tag. The total length of B2M/Beta-2 microglobulin Protein, Rat (119a.a, HEK293, C-His) is 119 a.a., with molecular weight of ~15 kDa.

作为 I 类主要组织相容性复合体 (MHC) 的重要组成部分，Beta-2 微球蛋白 (B2M) 在向免疫系统呈递肽抗原方面发挥着关键作用，有助于免疫监视和反应。B2M 在异二聚体结构内运作，与 α 链形成复合物，产生主要组织相容性复合物 I 类分子，促进免疫细胞识别抗原。值得注意的是，B2M 在这种分子排列中充当 β 链。此外，它还参与与 MR1 和代谢物抗原形成异源三聚体，扩大其在抗原呈递和免疫信号通路中的参与。复杂的相互作用和分子伙伴关系强调了 B2M 在通过识别和呈递抗原来协调免疫反应中的重要性。

Data is not available

Rat

HEK293

C-6*His

P07151 (M1-M119)

24223  [NCBI]

MARSVTVIFLVLVSLAVVLAIQKTPQIQVYSRHPPENGKPNFLNCYVSQFHPPQIEIELLKNGKKIPNIEMSDLSFSKDWSFYILAHTEFTPTETDVYACRVKHVTLKEPKTVTWDRDM

Approximately 15 kDa

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US;may vary elsewhere.