BCAP31 蛋白, Human (GST)

The BCAP31 protein acts as a chaperone and is one of the most abundant endoplasmic reticulum (ER) proteins. The BCAP31 protein also serves as a cargo receptor for transmembrane protein export. BCAP31 stimulates the translocation of NDUFS4 and NDUFB11 to mitochondria, interacts with BCL2, and may be involved in caspase-8-mediated apoptosis. BCAP31 Protein, Human (GST) is the recombinant human-derived BCAP31 protein, expressed by E. coli , with N-GST labeled tag. The total length of BCAP31 Protein, Human (GST) is 242 a.a., with molecular weight of ~54.5 kDa.

BCAP31 充当伴侣蛋白，被认为是最丰富的内质网 (ER) 蛋白之一。它的作用跨越细胞过程的各个方面，包括作为内质网中分泌蛋白输出的伴侣，帮助识别异常折叠的蛋白并引导它们进行内质网相关降解（ERAD）。此外，BCAP31 还充当跨膜蛋白输出的货物受体。值得注意的是，它通过与 TOMM40 相互作用促进 NDUFS4 和 NDUFB11 从细胞质易位到线粒体，从而有助于线粒体膜呼吸链 NADH 脱氢酶（复合物 I）的组装。在内质网应激条件下，BCAP31 从内质网-线粒体接触位点发生离域并与 BCL2 结合。它参与 CASP8 介导的细胞凋亡，并与 BCAP29 形成同二聚体或异二聚体。BCAP31 是涉及 BCAP29、BCL2 和/或 BCL2L1 的复合物的一部分，它与各种蛋白质（例如 TOMM40、VDAC1、VAMP3、VAMP1、膜 IgD 免疫球蛋白和 HACD2）相互作用，展示了其在细胞过程和蛋白质-蛋白质中的多方面作用。互动。

Human

E. coli

N-GST

P51572 (2S-243K)

10134  [NCBI]

SLQWTAVATFLYAEVFVVLLLCIPFISPKRWQKIFKSRLVELLVSYGNTFFVVLIVILVLLVIDAVREIRKYDDVTEKVNLQNNPGAMEHFHMKLFRAQRNLYIAGFSLLLSFLLRRLVTLISQQATLLASNEAFKKQAESASEAAKKYMEENDQLKKGAAVDGGKLDVGNAEVKLEEENRSLKADLQKLKDELASTKQKLEKAENQVLAMRKQSEGLTKEYDRLLEEHAKLQAAVDGPMDK

Approximately 54.5 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.