2. 重组蛋白
  3. Receptor Proteins
  4. G-Protein-Coupled Receptors (GPCRs)
  5. CT Receptor (Calcitonin Receptor)
  6. Calcitonin R 蛋白, Human (HEK293, Fc)

Calcitonin R 蛋白, Human (HEK293, Fc)

目录号: HY-P74358
产品使用指南

降钙素 R 蛋白是降钙素的受体，利用 G 蛋白激活腺苷酸环化酶。尽管对霍乱毒素敏感，但它与 G 蛋白的偶联有限，导致无法有效激活腺苷酸环化酶。值得注意的是，配体结合后，降钙素 R 不经历受体内化的常规过程。Calcitonin R 蛋白, Human (HEK293, Fc) 是重组的 降钙素 R 蛋白，由 HEK293 表达，带有 C-hFc 标签。Calcitonin R 蛋白, Human (HEK293, Fc) 全长 129 个氨基酸，分子量约为 ~42.1 kDa。

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描述

Calcitonin R protein, a receptor for calcitonin, utilizes G proteins to activate adenylyl cyclase. Despite being sensitive to cholera toxin, it exhibits limited coupling to G proteins, leading to the inability to effectively activate adenylyl cyclase. Notably, following ligand binding, Calcitonin R does not undergo the conventional process of receptor internalization. Calcitonin R Protein, Human (HEK293, Fc) is the recombinant human-derived Calcitonin R protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Calcitonin R Protein, Human (HEK293, Fc) is 129 a.a., with molecular weight of ~42.1 kDa.
研究背景

降钙素 R 蛋白作为降钙素受体，通过随后激活腺苷酸环化酶的 G 蛋白发挥其活性。据信该受体与对霍乱毒素敏感的异源三聚体 G 蛋白偶联。然而值得注意的是，虽然降钙素R作为降钙素的受体，但它并不能有效地与G蛋白偶联，导致无法激活腺苷酸环化酶。此外，在配体结合后，该受体不经历典型的受体内化过程。
种属

Human
表达系统

HEK293
标签

C-hFc
蛋白编号

P30988 (A25-I153)
基因 ID

799  [NCBI]
蛋白结构
N-term
CALCR (A25-I153)
Accession # P30988
hFc
C-term
同用名
Calcitonin R; Calcitonin receptor; CALCR; CRT; CTR; CTR1
分子量

Approximately 42.1 kDa
纯度

Greater than 90% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

Calcitonin R Protein, Human (HEK293, Fc) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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