CFHR5 蛋白, Human (HEK293, His)

CFHR5 is a first-line complement regulator that is actively involved in the complex dynamics of the regulatory system. Dimeric CFHR5 has significant affinity for tissue-bound complement fragments, thereby challenging CFH. CFHR5 Protein, Human (HEK293, His) is the recombinant human-derived CFHR5 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of CFHR5 Protein, Human (HEK293, His) is 551 a.a., with molecular weight of ~61.0 kDa.

CFHR5 站在补体监管的最前沿，积极参与该监管系统的复杂动态。在二聚化形式下，CFHR5 对组织结合的补体片段表现出显着的亲和力，有效挑战生理补体抑制剂 CFH。这种多功能调节剂参与头尾同源二聚体配置，并与 CFHR1 或 CFHR2 形成异二聚体，强调了其在协调补体相关过程中的适应性作用。此外，CFHR5 表现出体外结合 C3b 的能力，为其相互作用库添加了额外的一层，并强调了其在补体途径调节中的复杂参与。

Human

HEK293

C-6*His

Q9BXR6 (E19-E569)

81494  [NCBI]

EGTLCDFPKIHHGFLYDEEDYNPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEGWSPTPKCLRMCSFPFVKNGHSESSGLIHLEGDTVQIICNTGYSLQNNEKNISCVERGWSTPPICSFTKGECHVPILEANVDAQPKKESYKVGDVLKFSCRKNLIRVGSDSVQCYQFGWSPNFPTCKGQVRSCGPPPQLSNGEVKEIRKEEYGHNEVVEYDCNPNFIINGPKKIQCVDGEWTTLPTCVEQVKTCGYIPELEYGYVQPSVPPYQHGVSVEVNCRNEYAMIGNNMITCINGIWTELPMCVATHQLKRCKIAGVNIKTLLKLSGKEFNHNSRIRYRCSDIFRYRHSVCINGKWNPEVDCTEKREQFCPPPPQIPNAQNMTTTVNYQDGEKVAVLCKENYLLPEAKEIVCKDGRWQSLPRCVESTAYCGPPPSINNGDTTSFPLSVYPPGSTVTYRCQSFYKLQGSVTVTCRNKQWSEPPRCLDPCVVSEENMNKNNIQLKWRNDGKLYAKTGDAVEFQCKFPHKAMISSPPFRAICQEGKFEYPICE

Approximately 61.0 kDa

Greater than 95% as determined by reducing SDS-PAGE

无菌粉末

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.