CHI3L1 蛋白, Mouse (360a.a, HEK293, His)

CHI3L1 Protein, a carbohydrate-binding lectin with a preference for chitin, participates in tissue remodeling and cellular adaptation to environmental changes. It is involved in Th2 inflammation, IL-13-induced inflammation, allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation, M2 macrophage differentiation, and pathogenic enteric bacteria invasion. In colonic epithelial cells, it activates the AKT1 signaling pathway, leading to IL8 production. It also enhances antibacterial responses in the lung and regulates hyperoxia-induced injury and inflammation. CHI3L1 exists as a monomer. CHI3L1 Protein, Mouse (360a.a, HEK293, His) is the recombinant mouse-derived CHI3L1 protein, expressed by HEK293 , with C-His labeled tag. The total length of CHI3L1 Protein, Mouse (360a.a, HEK293, His) is 360 a.a., with molecular weight of 42-50 kDa.

CHI3L1 蛋白是一种碳水化合物结合凝集素，对几丁质表现出特定的偏好。尽管它缺乏几丁质酶活性，但它在组织重塑中发挥着至关重要的作用，并使细胞能够适应和响应环境变化。它参与多种过程，例如2型辅助性T细胞（Th2）炎症反应、IL-13诱导的炎症、过敏原致敏的调节、炎症细胞凋亡的调节、树突状细胞积累和促进M2巨噬细胞分化。此外，它还促进致病性肠道细菌侵入结肠粘膜和淋巴器官。在结肠上皮细胞中，它介导 AKT1 信号通路的激活，导致随后产生 IL8。 CHI3L1 还通过增强巨噬细胞杀灭细菌、控制细菌传播和促进宿主耐受来调节肺部的抗菌反应。此外，它还在调节肺中高氧诱导的损伤、炎症和上皮细胞凋亡中发挥作用。它以单体形式存在。

Mouse

HEK293

C-His

Q61362 (Y30-A389)

12654  [NCBI]

42-50 kDa

Greater than 95% as determined by Tris-Bis PAGE.

<1 EU/μg, determined by LAL method.