CLCN3 蛋白, Human (Cell-Free, His)

CLCN3 protein, a member of the CLC channel family, acts as an outwardly rectifying, electrogenic H(+)/Cl(-) exchanger. It facilitates the exchange of chloride ions for protons, reflecting its role in dynamic ion exchange. The conserved gating glutamate residues in the CLC family suggest their functionality as antiporters, emphasizing CLCN3's robust outward rectification and electrogenic nature in chloride and proton exchange. CLCN3 Protein, Human (Cell-Free, His) is the recombinant human-derived CLCN3 protein, expressed by E. coli Cell-free , with C-6*His labeled tag. The total length of CLCN3 Protein, Human (Cell-Free, His) is 818 a.a., with molecular weight of 93.2 kDa.

CLCN3 蛋白作为强向外整流、产电的 H(+)/Cl(-) 交换器发挥作用，促进氯离子与质子的交换。作为 CLC 通道家族（包括氯离子通道和质子耦合阴离子转运蛋白）的成员，CLCN3 参与氯离子或另一种阴离子与质子的交换。该家族特有的保守门控谷氨酸残基表明其成员具有逆向转运蛋白的功能。CLCN3 强大的外向整流和生电性质强调了其在氯离子和质子之间动态交换中的作用。

Human

E. coli Cell-free

C-6*His

P51790 (M1-N818)

1182

MASMTGGQQMGRDPMESEQLFHRGYYRNSYNSITSASSDEELLDGAGVIMDFQTSEDDNLLDGDTAVGTHYTMTNGGSINSSTHLLDLLDEPIPGVGTYDDFHTIDWVREKCKDRERHRRINSKKKESAWEMTKSLYDAWSGWLVVTLTGLASGALAGLIDIAADWMTDLKEGICLSALWYNHEQCCWGSNETTFEERDKCPQWKTWAELIIGQAEGPGSYIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLMIKTITLVLAVASGLSLGKEGPLVHVACCCGNIFSYLFPKYSTNEAKKREVLSAASAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFVLRSINPFGNSRLVLFYVEYHTPWYLFELFPFILLGVFGGLWGAFFIRANIAWCRRRKSTKFGKYPVLEVIIVAAITAVIAFPNPYTRLNTSELIKELFTDCGPLESSSLCDYRNDMNASKIVDDIPDRPAGIGVYSAIWQLCLALIFKIIMTVFTFGIKVPSGLFIPSMAIGAIAGRIVGIAVEQLAYYHHDWFIFKEWCEVGADCITPGLYAMVGAAACLGGVTRMTVSLVVIVFELTGGLEYIVPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLDAKEEFTHTTLAADVMRPRRNDPPLAVLTQDNMTVDDIENMINETSYNGFPVIMSKESQRLVGFALRRDLTIAIESARKKQEGIVGSSRVCFAQHTPSLPAESPRPLKLRSILDMSPFTVTDHTPMEIVVDIFRKLGLRQCLVTHNGRLLGIITKKDILRHMAQTANQDPASIMFN

93.2 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.