2. 重组蛋白
  3. Receptor Proteins
  4. CMKLR2 蛋白, Rat (Cell-Free, His)

CMKLR2 蛋白, Rat (Cell-Free, His)

目录号: HY-P702252
产品使用指南

CMKLR2 蛋白是凯莫瑞/RARRES2 的受体，通过 G 蛋白和 MAPK1/MAPK3 途径调节炎症和能量稳态。它还充当 TAFA1 受体，通过 ROCK/ERK 和 ROCK/STAT3 信号传导影响神经元干细胞过程。CMKLR2 蛋白, Rat (Cell-Free, His) 是重组的 CMKLR2 蛋白，由 E. coli Cell-free 表达，带有 N-10*His 标签。CMKLR2 蛋白, Rat (Cell-Free, His) 全长 353 个氨基酸，分子量为 42.4 kDa。

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描述

CMKLR2 Protein, a receptor for chemerin/RARRES2, regulates inflammation and energy homeostasis through G proteins and MAPK1/MAPK3 pathways. It also serves as a TAFA1 receptor, impacting neuronal stem-cell processes via ROCK/ERK and ROCK/STAT3 signaling. CMKLR2 Protein, Rat (Cell-Free, His) is the recombinant rat-derived CMKLR2 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of CMKLR2 Protein, Rat (Cell-Free, His) is 353 a.a., with molecular weight of 42.4 kDa.
研究背景

CMKLR2 蛋白作为趋化剂脂肪因子凯莫瑞 / RARRES2 的受体发挥作用，这意味着它参与炎症和能量稳态的调节。RARRES2 结合主要通过 β-arrestin 通路发挥作用，激活 G 蛋白，诱导钙动员，并触发 MAPK1/MAPK3 (ERK1/2) 磷酸化。此外，CMKLR2 作为 TAFA1 的受体，通过激活 ROCK/ERK 和 ROCK/STAT3 信号通路促进 TAFA1 对神经元干细胞增殖和分化的影响。
种属

Rat
表达系统

E. coli Cell-free
标签

N-10*His
蛋白编号

P46090 (M1-Q353)
基因 ID

25457
蛋白结构
N-term
10*His
CMKLR2 (M1-Q353)
Accession # P46090
C-term
同用名
Chemerin-like receptor 2; Chemerin chemokine-like receptor 2; Chemokine-like receptor 2; G-protein coupled receptor 1
氨基酸序列

MEVSREMLFEELDNYSYALEYYSQEPDAEENVYPGIVHWISLLLYALAFVLGIPGNAIVIWFMGFKWKKTVTTLWFLNLAIADFVFVLFLPLYISYVALSFHWPFGRWLCKLNSFIAQLNMFSSVFFLTVISLDRYIHLIHPGLSHPHRTLKNSLLVVLFVWLLASLLGGPTLYFRDTVEVNNRIICYNNFQEYELTLMRHHVLTWVKFLFGYLLPLLTMSSCYLCLIFKTKKQNILISSKHLWMILSVVIAFMVCWTPFHLFSIWELSIHHNSSFQNVLQGGIPLSTGLAFLNSCLNPILYVLISKKFQARFRASVAEVLKRSLWEASCSGTVSEQLRSAETKSLSLLETAQ

分子量

42.4 kDa
纯度

Greater than 90% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

CMKLR2 Protein, Rat (Cell-Free, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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