CNGA4 蛋白, Human (Cell-Free, His, SUMO)

The CNGA4 protein is a regulatory subunit of cation-selective cyclic nucleotide-gated (CNG) channels in olfactory sensory neurons that responds to cAMP to induce depolarization. This critical role in odorant signal transduction and adaptation enhances neural responses to olfactory stimulation. CNGA4 Protein, Human (Cell-Free, His, SUMO) is the recombinant human-derived CNGA4 protein, expressed by E. coli Cell-free , with N-6*His, N-SUMO labeled tag. The total length of CNGA4 Protein, Human (Cell-Free, His, SUMO) is 575 a.a., with molecular weight of 82 kDa.

CNGA4 蛋白作为阳离子选择性环核苷酸门控 (CNG) 通道的调节亚基，响应第二信使 cAMP 并诱导嗅觉感觉神经元 (OSN) 去极化。这些通道在传导气味信号和随后的适应中发挥着关键作用，有助于对各种嗅觉刺激的神经反应。CNGA4通过加速嗅觉信号中钙介导的负反馈，促进对气味刺激的快速适应，从而扩大气味检测范围。钙-钙调蛋白对 cAMP 敏感性的抑制作用涉及其与 CNGA4 的 IQ 样基序的结合，并优先选择通道的关闭状态。此外，PIP3 对 CNG 通道的抑制可能是通过 CGNA2 结合发生的，这凸显了控制嗅觉信号转导的复杂调节机制。

Human

E. coli Cell-free

N-6*His;N-SUMO

Q8IV77 (M1-E575)

1262

MSQDTKVKTTESSPPAPSKARKLLPVLDPSGDYYYWWLNTMVFPVMYNLIILVCRACFPDLQHGYLVAWLVLDYTSDLLYLLDMVVRFHTGFLEQGILVVDKGRISSRYVRTWSFFLDLASLMPTDVVYVRLGPHTPTLRLNRFLRAPRLFEAFDRTETRTAYPNAFRIAKLMLYIFVVIHWNSCLYFALSRYLGFGRDAWVYPDPAQPGFERLRRQYLYSFYFSTLILTTVGDTPPPAREEEYLFMVGDFLLAVMGFATIMGSMSSVIYNMNTADAAFYPDHALVKKYMKLQHVNRKLERRVIDWYQHLQINKKMTNEVAILQHLPERLRAEVAVSVHLSTLSRVQIFQNCEASLLEELVLKLQPQTYSPGEYVCRKGDIGQEMYIIREGQLAVVADDGITQYAVLGAGLYFGEISIINIKGNMSGNRRTANIKSLGYSDLFCLSKEDLREVLSEYPQAQTIMEEKGREILLKMNKLDVNAEAAEIALQEATESRLRGLDQQLDDLQTKFARLLAELESSALKIAYRIERLEWQTREWPMPEDLAEADDEGEPEEGTSKDEEGRASQEGPPGPE

82 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.