1. 重组蛋白
  2. Cytokines and Growth Factors
  3. TNF Superfamily
  4. TNF Receptor Superfamily
  5. Decoy Receptor 1
  6. TNFRSF10C, Human (HEK 293, His)

TNFRSF10C, Human (HEK 293, His)

目录号: HY-P72278
产品使用指南

TNFRSF10C 蛋白是 TRAIL 的受体,缺乏细胞质死亡结构域,因此无法诱导细胞凋亡。相反,它通过竞争与 TRAIL-R1 和 R2 的配体结合来保护细胞,充当诱饵受体并减轻 TRAIL 介导的细胞凋亡。TNFRSF10C, Human (HEK 293, His) 是重组的 TNFRSF10C,由 HEK293 表达,带有 C-6*His 标签。TNFRSF10C, Human (HEK 293, His) 全长 196 个氨基酸,分子量约为 ~40.0 kDa。

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该产品已“停产”。 等效替代: HY-P70815

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描述

The TNFRSF10C protein is a receptor for TRAIL and lacks a cytoplasmic death domain, making it unable to induce apoptosis. Instead, it protects cells by competing for ligand binding with TRAIL-R1 and R2, acting as a decoy receptor and mitigating TRAIL-mediated apoptosis. TNFRSF10C, Human (HEK 293, His) is the recombinant human-derived TNFRSF10C, expressed by HEK293 , with C-6*His labeled tag. The total length of TNFRSF10C, Human (HEK 293, His) is 196 a.a., with molecular weight of ~40.0 kDa.

研究背景

TNFRSF10C 蛋白作为细胞毒性配体 TRAIL 的受体;然而,它缺乏细胞质死亡结构域,使其无法诱导细胞凋亡。相反,TNFRSF10C 可能通过与 TRAIL-R1 和 R2 竞争与配体的结合,在细胞中发挥保护作用,可能充当诱饵受体,从而减轻 TRAIL 介导的细胞凋亡。这一独特的特征凸显了 TNFRSF10C 在调节细胞对 TRAIL 信号反应的反应中的调节复杂性,并表明它参与微调生存和凋亡途径之间的平衡。

种属

Human

表达系统

HEK293

标签

C-6*His

蛋白编号

O14798 (A26-A221)

基因 ID
蛋白结构
N-term
TNFRSF10C (A26-A221)
Accession # O14798
6*His
C-term
同用名
TNFRSF10C; TRAILR3; TRAIL receptor 3; TRAIL-R3; CD antigen CD263; Tumor necrosis factor receptor superfamily member 10
氨基酸序列

ATTARQEEVPQQTVAPQQQRHSFKGEECPAGSHRSEHTGACNPCTEGVDYTNASNNEPSCFPCTVCKSDQKHKSSCTMTRDTVCQCKEGTFRNENSPEMCRKCSRCPSGEVQVSNCTSWDDIQCVEEFGANATVETPAAEETMNTSPGTPAPAAEETMNTSPGTPAPAAEETMTTSPGTPAPAAEETMTTSPGTPA

分子量

Approximately 40.0 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE.

内毒素含量

<11 EU/μg, determined by LAL method.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
TNFRSF10C, Human (HEK 293, His)
目录号:
HY-P72278
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