1. 重组蛋白
  2. Enzymes & Regulators
  3. Transferases (EC 2)
  4. DMPK 蛋白, Human (Sf9, His)

DMPK 蛋白, Human (Sf9, His)

目录号: HY-P701666
产品使用指南

DMPK 是一种非受体丝氨酸/苏氨酸蛋白激酶,对于骨骼肌完整性至关重要,影响肌细胞分化、核膜完整性和肌肉特异性基因表达。它可能抑制肌球蛋白磷酸酶 (PPP1R12A),调节肌球蛋白磷酸化并影响心肌收缩力和传导。DMPK 蛋白, Human (Sf9, His) 是重组的 DMPK 蛋白,由 Sf9 insect cells 表达,带有 N-6*His 标签。DMPK 蛋白, Human (Sf9, His) 全长 629 个氨基酸。

MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

重组蛋白定制服务

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 是否有货
50 μg   询价  
100 μg   询价  

* Please select Quantity before adding items.

  • 生物活性

  • 技术参数

  • 产品性质

  • 产品资料

描述

DMPK is a non-receptor serine/threonine protein kinase that is critical for skeletal muscle integrity, affecting myocyte differentiation, nuclear membrane integrity, and muscle-specific gene expression. It may inhibit myosin phosphatase (PPP1R12A), regulate myosin phosphorylation and affect cardiac contractility and conduction. DMPK Protein, Human (Sf9, His) is the recombinant human-derived DMPK protein, expressed by Sf9 insect cells , with N-6*His labeled tag. The total length of DMPK Protein, Human (Sf9, His) is 629 a.a., .

研究背景

DMPK 是一种非受体丝氨酸/苏氨酸蛋白激酶,对于维持骨骼肌的结构和功能完整性至关重要。它可能通过影响核膜的完整性和肌肉特异性基因的表达来促进肌细胞的分化和存活。此外,DMPK 可能磷酸化 PPP1R12A,抑制肌球蛋白磷酸酶活性,从而调节肌球蛋白磷酸化。这种激酶对于调节心肌收缩力和确保适当的心脏传导活动至关重要,可能是通过调节细胞钙稳态来实现的。DMPK 的参与延伸到磷酸化 PLN(钙泵的调节剂),表明其在调节肌细胞中肌浆网钙摄取中发挥作用。此外,DMPK 可能会磷酸化 FXYD1/PLM(以诱导氯电流而闻名),并且也可能在突触可塑性中发挥作用。

种属

Human

表达系统

Sf9 insect cells

标签

N-6*His

蛋白编号

Q09013 (M1-P629)

基因 ID

1760

蛋白结构
N-term
6*His
DMPK (M1-P629)
Accession # Q09013
C-term
同用名
DMPK; Myotonin-protein kinase; MT-PK; DM-kinase; DMK; DM1 protein kinase; DMPK; Myotonic dystrophy protein kinase
纯度

Greater than 90% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料

DMPK Protein, Human (Sf9, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称:

 

* 需求量:

* 客户姓名:

 

* Email:

* 电话:

 

* 公司或机构名称:

   留言给我们:

Bulk Inquiry

Inquiry Information

产品名称:
DMPK Protein, Human (Sf9, His)
目录号:
HY-P701666
需求量: