Envelope small membrane 蛋白, HCoV-NL63 (Cell-Free, His)

Enveloped small membrane proteins play a central role in viral morphogenesis and assembly, acting as viroporins that self-assemble in the host membrane to form homopentameric protein-lipid pores that facilitate ion transport. In addition to virus formation, it induces apoptosis and interacts with membrane protein M in the budding compartment of the host cell while binding to nuclear proteins. Envelope small membrane Protein, HCoV-NL63 (Cell-Free, His) is the recombinant Virus-derived Envelope small membrane protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of Envelope small membrane Protein, HCoV-NL63 (Cell-Free, His) is 77 a.a., with molecular weight of 12.0 kDa.

包膜小膜蛋白在病毒形态发生和组装中发挥核心作用，作为病毒孔蛋白在宿主膜中自组装，形成同源五聚体蛋白-脂质孔，促进离子运输。除了参与病毒形成之外，它还在诱导细胞凋亡中发挥重要作用。该蛋白以同五聚体形式存在，与位于内质网和高尔基复合体之间的宿主细胞出芽室中的膜蛋白 M 相互作用。此外，它与核蛋白结合，促进对宿主细胞环境中病毒生命周期至关重要的蛋白质的复杂相互作用。包膜小膜蛋白的多方面功能凸显了其在病毒组装、膜相互作用和细胞凋亡诱导的动态过程中的关键作用。

Virus

E. coli Cell-free

N-10*His

Q6Q1S0 (M1-V77)

2943502

MFLRLIDDNGIVLNSILWLLVMIFFFVLAMTFIKLIQLCFTCHYFFSRTLYQPVYKIFLAYQDYMQIAPVPAEVLNV

12.0 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.