FOLR3 蛋白, Human (HEK293, His)

FOLR3 protein is crucial in folate metabolism, binding to folate and aiding 5-methyltetrahydrofolate delivery into cells. Notably, the Isoform Short of FOLR3 lacks folate-binding capabilities, indicating diverse functional roles among FOLR3 isoforms. This highlights nuanced regulation in cellular folate transport processes. FOLR3 Protein, Human (HEK293, His) is the recombinant human-derived FOLR3 protein, expressed by HEK293, with C-His labeled tag. The total length of FOLR3 Protein, Human (HEK293, His) is 223 a.a., with molecular weight of 33-45 kDa.

FOLR3 蛋白在叶酸代谢中发挥着关键作用，与叶酸结合并还原叶酸衍生物，同时促进 5-甲基四氢叶酸输送到细胞内部。值得注意的是，FOLR3 的短异构体不表现出叶酸结合能力。这种不同的结合行为表明 FOLR3 的各种亚型具有不同的功能作用，强调了细胞过程中叶酸转运的微妙调节。

Human FOLR3 protein captured on CM5 chip can bind Folic acid with an affinity constant of 0.122 nM as detected by SPR assay(Biacore T200).

Human

HEK293

C-His

P41439 (Q23-S245)

2352  [NCBI]

33-45 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized a 0.22 μm filtered solution of 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.