GH1/Somatotropin 蛋白, Human (HEK293, N-His, C-Myc)

Growth hormone (GH) plays a key role in growth control, stimulating the release of insulin-like growth factor 1 (IGF-1) from the liver and tissues to promote body growth. It regulates myoblast differentiation and proliferation and contributes significantly to overall organismal development. GH1/Somatotropin Protein, Human (HEK293, N-His, C-Myc) is the recombinant human-derived GH1/Somatotropin protein, expressed by HEK293 , with C-Myc, N-10*His labeled tag. The total length of GH1/Somatotropin Protein, Human (HEK293, N-His, C-Myc) is 191 a.a., with molecular weight of 27.2 kDa.

生长激素 (GH) 蛋白在生长控制中发挥着关键作用，通过刺激肝脏和其他组织分泌胰岛素样生长因子 1 (IGF-1) 对身体生长发挥主要影响。GH 作为成肌细胞分化和增殖的有效调节剂，对生物体的整体生长和发育做出了重大贡献。此外，它在增强肌肉和各种组织的氨基酸吸收和促进蛋白质合成方面发挥着至关重要的作用。在结构上，GH以多种形式存在，包括单体、二聚体、三聚体、四聚体和五聚体，无论是二硫键连接还是非共价连接，均聚和异聚组合。此外，GH 可以与 GH 结合蛋白 (GHBP) 或 α2-巨球蛋白复合物形成复合物，强调其多功能的分子相互作用，有助于其在生长调节和组织发育中的多方面作用。

Measured by its binding ability in a functional ELISA. Immobilized GH1 at 1 μg/mL can bind human GHR, the EC₅₀ of the protein is ≤25.29 ng/ml.

Human

HEK293

C-Myc;N-10*His

P01241 (F27-F217)

2688  [NCBI]

FPTIPLSRLFDNAMLRAHRLHQLAFDTYQEFEEAYIPKEQKYSFLQNPQTSLCFSESIPTPSNREETQQKSNLELLRISLLLIQSWLEPVQFLRSVFANSLVYGASDSNVYDLLKDLEEGIQTLMGRLEDGSPRTGQIFKQTYSKFDTNSHNDDALLKNYGLLYCFRKDMDKVETFLRIVQCRSVEGSCGF

27.2 kDa

Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.