HVCN1 蛋白, Mouse (Cell-Free, His)

The HVCN1 protein plays a crucial role in cellular function by mediating voltage-dependent proton permeability, forming proton-selective channels that allow protons to pass along electrochemical gradients. This channel promotes proton efflux, which in combination with membrane depolarization contributes to the generation of reactive oxygen species during phagocytosis. HVCN1 Protein, Mouse (Cell-Free, His) is the recombinant mouse-derived HVCN1 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of HVCN1 Protein, Mouse (Cell-Free, His) is 269 a.a., with molecular weight of 36.7 kDa.

HVCN1 蛋白通过介导可兴奋膜的电压依赖性质子渗透性，形成质子选择性通道，允许质子根据其电化学梯度通过，从而在细胞功能中发挥至关重要的作用。该通道促进质子流出，加上膜去极化，有助于吞噬过程中活性氧的急剧产生。值得注意的是，该蛋白质形成的二聚体表现出合作通道门控，强调了其调控机制的复杂性。此外，通道活性受到锌离子的抑制，为其功能添加了额外的调节层。HVCN1 控制质子渗透性的能力及其对膜电位变化的响应性强调了其在细胞过程中的重要性，特别是与吞噬作用和活性氧生成相关的细胞过程。

Mouse

E. coli Cell-free

N-10*His

Q3U2S8 (M1-N269)

74096

MTSHDPKAVTRRTKVAPTKRMSRFLKHFTVVGDDYHTWNVNYKKWENEEEEEEPAPTSAEGEGNAEGPDAEAGSASTPRQSLDFRSRLRKLFSSHRFQVIIICLVVLDALLVLAELLLDLKIIEPDEQDYAVTAFHYMSFAILVFFMLEIFFKIFVFRLEFFHHKFEILDAFVVVVSFVLDLVLLFKSHHFEALGLLILLRLWRVARIINGIIISVKTRSERQILRLKQINIQLATKIQHLEFSCSEKEQEIERLNKLLKQNGLLGDVN

36.7 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.