1. 重组蛋白
  2. CD Antigens Receptor Proteins
  3. B Cell CD Proteins Macrophage CD Proteins Monocyte CD Proteins Stem Cell CD Proteins Platelet CD Proteins Dendritic Cell CD Proteins Epithelial cell CD Proteins Endothelial cell CD Proteins Cell Adhesion Molecules (CAMs)
  4. CD29/Integrin beta-1 CD300e Integrin
  5. Integrin beta-1
  6. Integrin beta-1/CD29 蛋白, Human (728a.a, HEK293, His)

Integrin beta-1/CD29 蛋白, Human (728a.a, HEK293, His)

目录号: HY-P73862
产品使用指南

整合素 beta-1/CD29 形成独特的异二聚体,充当细胞外基质蛋白的多功能受体。它识别胶原蛋白、纤连蛋白、纤维蛋白原和层粘连蛋白,并在迁移、粘附和血管生成等细胞功能中发挥关键作用。Integrin beta-1/CD29 蛋白, Human (728a.a, HEK293, His) 是重组的 整合素 beta-1/CD29 蛋白,由 HEK293 表达,带有 C-8*His 标签。Integrin beta-1/CD29 蛋白, Human (728a.a, HEK293, His) 全长 708 个氨基酸,分子量为 90-145 kDa。

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该产品已“停产”。 等效替代: HY-P70257

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描述

Integrin beta-1/CD29 forms distinct heterodimers that act as multifunctional receptors for extracellular matrix proteins. It recognizes collagen, fibronectin, fibrinogen and laminin and plays a key role in cell functions such as migration, adhesion and angiogenesis. Integrin beta-1/CD29 Protein, Human (728a.a, HEK293, His) is the recombinant human-derived Integrin beta-1/CD29 protein, expressed by HEK293 , with C-8*His labeled tag. The total length of Integrin beta-1/CD29 Protein, Human (728a.a, HEK293, His) is 708 a.a., with molecular weight of 90-145 kDa.

研究背景

整合素 beta-1/CD29 蛋白与各种 α 亚基形成异二聚体,可作为多种细胞外基质蛋白的多功能受体。整合素 α-1/β-1、α-2/β-1、α-10/β-1 和 α-11/β-1 识别胶原蛋白,而整合素 α-2/β-2、α-3/ beta-1、alpha-4/beta-1、alpha-5/beta-1、alpha-8/beta-1、alpha-10/beta-1、alpha-11/beta-1 和 alpha-V/beta -1 作为纤连蛋白受体。此外,整合素 α-5/β-1 作为纤维蛋白原的受体,整合素 α-1/β-1、α-2/β-1、α-6/β-1 和 α-7/β- 1 是层粘连蛋白的受体。特定的整合素,例如 α-4/β-1 和 α-9/β-1,在识别 VCAM1 和其他配体中发挥作用,有助于多种细胞功能,包括迁移、粘附和血管生成。Beta-1 整合素可识别 RGD 序列,参与多种生理过程,例如成骨细胞压缩、细胞运动和胞质分裂完成。此外,整合素 beta-1/CD29 在促进细胞侵袭、基质降解和成肌细胞分化中发挥着关键作用,凸显了其在细胞粘附、信号传导和发育过程中的重要性。

种属

Human

表达系统

HEK293

标签

C-8*His

蛋白编号

P05556/CAA30790.1 (Q21-D728)

基因 ID
蛋白结构
N-term
ITGB1 (Q21-D728)
Accession # P05556/CAA30790.1
8*His
C-term
同用名
Integrin Beta-1; CD29; ITGB1; FNRB; MDF2; MSK12
氨基酸序列

QTDENRCLKANAKSCGECIQAGPNCGWCTNSTFLQEGMPTSARCDDLEALKKKGCPPDDIENPRGSKDIKKNKNVTNRSKGTAEKLKPEDIHQIQPQQLVLRLRSGEPQTFTLKFKRAEDYPIDLYYLMDLSYSMKDDLENVKSLGTDLMNEMRRITSDFRIGFGSFVEKTVMPYISTTPAKLRNPCTSEQNCTTPFSYKNVLSLTNKGEVFNELVGKQRISGNLDSPEGGFDAIMQVAVCGSLIGWRNVTRLLVFSTDAGFHFAGDGKLGGIVLPNDGQCHLENNMYTMSHYYDYPSIAHLVQKLSENNIQTIFAVTEEFQPVYKELKNLIPKSAVGTLSANSSNVIQLIIDAYNSLSSEVILENGKLSEGVTISYKSYCKNGVNGTGENGRKCSNISIGDEVQFEISITSNKCPKKDSDSFKIRPLGFTEEVEVILQYICECECQSEGIPESPKCHEGNGTFECGACRCNEGRVGRHCECSTDEVNSEDMDAYCRKENSSEICSNNGECVCGQCVCRKRDNTNEIYSGKFCECDNFNCDRSNGLICGGNGVCKCRVCECNPNYTGSACDCSLDTSTCEASNGQICNGRGICECGVCKCTDPKFQGQTCEMCQTCLGVCAEHKECVQCRAFNKGEKKDTCTQECSYFNITKVESRDKLPQPVQPDPVSHCKEKDVDDCWFYFTYSVNGNNEVMVHVVENPECPTGPD

分子量

90-145 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
Integrin beta-1/CD29 Protein, Human (728a.a, HEK293, His)
目录号:
HY-P73862
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