M6PR 蛋白, Human (Cell-Free, His)

M6PR, vital in cellular transport, guides phosphorylated lysosomal enzymes from Golgi and cell surface to lysosomes. Recognizing phosphomannosyl residues, it forms receptor-ligand complexes, transported to acidic prelyosomal compartments. Low pH triggers complex dissociation. M6PR, functioning as a homodimer, interacts with adaptors GGA1, GGA2, and GGA3, ensuring the precision of this transport mechanism. M6PR Protein, Human (Cell-Free, His) is the recombinant human-derived M6PR protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of M6PR Protein, Human (Cell-Free, His) is 251 a.a., with molecular weight of 30.7 kDa.

M6PR 是细胞运输过程中的关键参与者，促进磷酸化溶酶体酶从高尔基复合体和细胞表面向溶酶体的移动。这个复杂的系统依赖于携带磷酸甘露糖基残基的溶酶体酶，该残基选择性地与高尔基体内的甘露糖-6-磷酸受体结合。随后形成的受体-配体复合物被转运至酸性前溶酶体区室，其中低pH环境触发这些复合物的解离。值得注意的是，M6PR 作为同二聚体发挥作用，并与衔接蛋白 GGA1、GGA2 和 GGA3 相互作用，有助于这种复杂转运机制的精确性。

Human

E. coli Cell-free

N-10*His

P20645 (T27-M277)

4074

TEEKTCDLVGEKGKESEKELALVKRLKPLFNKSFESTVGQGSDTYIYIFRVCREAGNHTSGAGLVQINKSNGKETVVGRLNETHIFNGSNWIMLIYKGGDEYDNHCGKEQRRAVVMISCNRHTLADNFNPVSEERGKVQDCFYLFEMDSSLACSPEISHLSVGSILLVTFASLVAVYVVGGFLYQRLVVGAKGMEQFPHLAFWQDLGNLVADGCDFVCRSKPRNVPAAYRGVGDDQLGEESEERDDHLLPM

30.7 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.