MERTK 蛋白, Mouse (HEK293, His)

Mer Protein, a receptor tyrosine kinase, transduces signals by binding to ligands like LGALS3, TUB, TULP1, or GAS6. Crucial in processes such as cell survival, migration, differentiation, and apoptotic cell phagocytosis, Mer undergoes autophosphorylation upon ligand binding. This creates binding sites for downstream molecules, leading to interactions with GRB2 or PLCG2 and subsequent phosphorylation of MAPK1, MAPK2, FAK/PTK2, or RAC1. Mer signaling influences macrophage clearance, platelet aggregation, cytoskeleton reorganization, and engulfment. Notably, in the retinal pigment epithelium, Mer regulates phagocytosis of rod outer segment fragments. Additionally, Mer inhibits the innate immune response triggered by Toll-like receptors (TLRs) by activating STAT1, inducing the production of suppressors of cytokine signaling SOCS1 and SOCS3. MERTK Protein, Mouse (HEK293, His) is the recombinant mouse-derived MERTK protein, expressed by HEK293, with C-10*His labeled tag. The total length of MERTK Protein, Mouse (HEK293, His) is 479 a.a., with molecular weight of 55.0 kDa.

Mer 蛋白是一种受体酪氨酸激酶，通过与 LGALS3、TUB、TULP1 或 GAS6 等配体结合，介导从细胞外基质到细胞质的细胞信号传导。它在各种生理过程中发挥着至关重要的作用，包括细胞存活、迁移、分化和凋亡细胞的吞噬作用。通过配体结合激活 Mer 会导致其胞内结构域发生自磷酸化，从而为下游信号分子创建结合位点。这反过来又触发与 GRB2 或 PLCG2 的相互作用以及随后的 MAPK1、MAPK2、FAK/PTK2 或 RAC1 的磷酸化。Mer 信号传导参与巨噬细胞清除凋亡细胞、血小板聚集、细胞骨架重组和吞噬。值得注意的是，在视网膜色素上皮 (RPE) 内，Mer 作为视杆细胞外节片段吞噬作用的调节剂。此外，Mer 在通过激活 STAT1 抑制 Toll 样受体 (TLR) 触发的先天免疫反应中发挥着关键作用，STAT1 选择性诱导细胞因子信号转导 SOCS1 和 SOCS3 抑制剂的产生。

Mouse

HEK293

C-10*His

Q60805 (G19-M497)

17289  [NCBI]

GGTAEKWEETELDQLFSGPLPGRLPVNHRPFSAPHSSRDQLPPPQTGRSHPAHTAAPQVTSTASKLLPPVAFNHTIGHIVLSEHKNVKFNCSINIPNTYQETAGISWWKDGKELLGAHHSITQFYPDEEGVSIIALFSIASVQRSDNGSYFCKMKVNNREIVSDPIYVEVQGLPYFIKQPESVNVTRNTAFNLTCQAVGPPEPVNIFWVQNSSRVNEKPERSPSVLTVPGLTETAVFSCEAHNDKGLTVSKGVHINIKVIPSPPTEVHILNSTAHSILVSWVPGFDGYSPLQNCSIQVKEADRLSNGSVMVFNTSASPHLYEIQQLQALANYSIAVSCRNEIGWSAVSPWILASTTEGAPSVAPLNITVFLNESNNILDIRWTKPPIKRQDGELVGYRISHVWESAGTYKELSEEVSQNGSWAQIPVQIHNATCTVRIAAITKGGIGPFSEPVNIIIPEHSKVDYAPSSTPAPGNTDSM

55.0 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.