Myeloperoxidase/MPO 蛋白, Human (HEK293, C-His)

Myeloperoxidase (MPO) Protein is a crucial component of polymorphonuclear leukocytes, vital for microbicidal activity against diverse organisms. Upon leukocyte stimulation, MPO catalyzes the generation of hypohalous acids, predominantly hypochlorous acid, enhancing microbicidal activity. This enzymatic defense mechanism contributes to the host's ability to combat pathogens. Additionally, MPO is involved in proteolytic cleavage of alpha-1-microglobulin, generating t-alpha-1-microglobulin, which inhibits low-density lipoprotein oxidation, providing vascular protection. MPO's multifaceted functions highlight its critical role in immune defense and vascular health. Myeloperoxidase/MPO Protein, Human (HEK293, C-His) is the recombinant human-derived Myeloperoxidase/MPO protein, expressed by HEK293, with C-6*His labeled tag. The total length of Myeloperoxidase/MPO Protein, Human (HEK293, C-His) is 697 a.a., with molecular weight of approximately 95 kDa.

髓过氧化物酶 (MPO) 蛋白是多形核白细胞内宿主防御系统的重要组成部分，在针对多种生物体的杀菌活性中发挥着关键作用。在刺激多形核白细胞时，MPO 催化产生次卤酸，在生理条件下主要是次氯酸，以及其他有毒中间体，可显着增强这些细胞的杀菌活性。这种酶活性是一种有效的防御机制，有助于宿主对抗各种病原体的能力。此外，MPO 参与 α-1-微球蛋白的蛋白水解裂解，产生 t-α-1-微球蛋白，这种分子以其抑制低密度脂蛋白颗粒氧化的能力而闻名，从而减轻血管损伤。这些多方面的功能强调了 MPO 在免疫防御和血管保护中的关键作用。

Human

HEK293

C-6*His

P05164 (A49-S745)

4353  [NCBI]

AAPAVLGEVDTSLVLSSMEEAKQLVDKAYKERRESIKQRLRSGSASPMELLSYFKQPVAATRTAVRAADYLHVALDLLERKLRSLWRRPFNVTDVLTPAQLNVLSKSSGCAYQDVGVTCPEQDKYRTITGMCNNRRSPTLGASNRAFVRWLPAEYEDGFSLPYGWTPGVKRNGFPVALARAVSNEIVRFPTDQLTPDQERSLMFMQWGQLLDHDLDFTPEPAARASFVTGVNCETSCVQQPPCFPLKIPPNDPRIKNQADCIPFFRSCPACPGSNITIRNQINALTSFVDASMVYGSEEPLARNLRNMSNQLGLLAVNQRFQDNGRALLPFDNLHDDPCLLTNRSARIPCFLAGDTRSSEMPELTSMHTLLLREHNRLATELKSLNPRWDGERLYQEARKIVGAMVQIITYRDYLPLVLGPTAMRKYLPTYRSYNDSVDPRIANVFTNAFRYGHTLIQPFMFRLDNRYQPMEPNPRVPLSRVFFASWRVVLEGGIDPILRGLMATPAKLNRQNQIAVDEIRERLFEQVMRIGLDLPALNMQRSRDHGLPGYNAWRRFCGLPQPETVGQLGTVLRNLKLARKLMEQYGTPNNIDIWMGGVSEPLKRKGRVGPLLACIIGTQFRKLRDGDRFWWENEGVFSMQQRQALAQISLPRIICDNTGITTVSKNNIFMSNSYPRDFVNCSTLPALNLASWREAS

approximately 95 kDa

• 
  Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.