2. 重组蛋白
  3. Receptor Proteins
  4. P2RY12 蛋白, Mouse (Cell-Free, His)

P2RY12 蛋白, Mouse (Cell-Free, His)

目录号: HY-P702411
产品使用指南

P2RY12蛋白是ADP和ATP的受体，通过G蛋白抑制腺苷酸环化酶第二信使系统。P2RY12 对于正常血小板聚集和凝血至关重要，它介导对核苷酸信号的反应。P2RY12 蛋白, Mouse (Cell-Free, His) 是重组的 P2RY12 蛋白，由 E. coli Cell-free 表达，带有 N-10*His 标签。P2RY12 蛋白, Mouse (Cell-Free, His) 全长 347 个氨基酸，分子量为 45.5 kDa。

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描述

P2RY12 protein is a receptor for ADP and ATP and inhibits adenylyl cyclase second messenger system through G protein. P2RY12 is critical for normal platelet aggregation and coagulation, where it mediates responses to nucleotide signals. P2RY12 Protein, Mouse (Cell-Free, His) is the recombinant mouse-derived P2RY12 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of P2RY12 Protein, Mouse (Cell-Free, His) is 347 a.a., with molecular weight of 45.5 kDa.
研究背景

P2RY12 蛋白被确定为 ADP 和 ATP 的受体，通过 G 蛋白发挥作用，抑制腺苷酸环化酶第二信使系统。P2RY12 对于正常血小板聚集和血液凝固至关重要，在介导对这些过程中涉及的核苷酸信号的反应中发挥着至关重要的作用。通过其受体功能，它作为血小板活化的关键调节剂，有助于复杂的止血和凝血机制。P2RY12 对腺苷酸环化酶第二信使系统的抑制强调了其在协调细胞反应中的重要性，并强调了其作为调节血小板功能和凝血的治疗靶点的潜力。
种属

Mouse
表达系统

E. coli Cell-free
标签

N-10*His
蛋白编号

Q9CPV9 (M1-M347)
基因 ID

70839
蛋白结构
N-term
10*His
P2RY12 (M1-M347)
Accession # Q9CPV9
C-term
同用名
P2Y purinoceptor 12; P2Y12
氨基酸序列

MDVPGVNTTSANTTFSPGTSTLCVRDYKITQVLFPLLYTVLFFAGLITNSLAMRIFFQIRSKSNFIIFLKNTVISDLLMILTFPFKILSDAKLGAGPLRTLVCQVTSVTFYFTMYISISFLGLITIDRYLKTTRPFKTSSPSNLLGAKILSVVIWAFMFLISLPNMILTNRRPKDKDVTKCSFLKSEFGLVWHEIVNYICQVIFWINFLIVIVCYSLITKELYRSYVRTRGSAKVPKKKVNVKVFIIIAVFFICFVPFHFARIPYTLSQTRAVFDCSAENTLFYVKESTLWLTSLNACLDPFIYFFLCKSFRNSLTSMLRCSNSTSTSGTNKKKGQEGGEPSEETPM

分子量

45.5 kDa
纯度

Greater than 90% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

P2RY12 Protein, Mouse (Cell-Free, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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