SLC26A4 蛋白, Human (Cell-Free, His)

SLC26A4 Protein, a sodium-independent transporter, crucially facilitates chloride and iodide transport, mediating electroneutral chloride-bicarbonate, chloride-iodide, and chloride-formate exchanges, each with a 1:1 stoichiometry. It's also implicated in electroneutral iodide-bicarbonate exchange, highlighting its versatility in transporting essential anions. The precise stoichiometry and electrogenic nature underscore its significance in maintaining cellular ion balance and regulating chloride and iodide ions. SLC26A4 emerges as a key player in cellular physiology, contributing to critical processes where chloride and iodide homeostasis is essential. SLC26A4 Protein, Human (Cell-Free, His) is the recombinant human-derived SLC26A4 protein, expressed by E. coli Cell-free , with N-6*His labeled tag and H723R mutation. The total length of SLC26A4 Protein, Human (Cell-Free, His) is 780 a.a., with molecular weight of 86.7 kDa.

SLC26A4 是一种不依赖于钠的转运蛋白，可促进氯离子和碘离子的转运。这种转运蛋白在各种研究中都有记录，在介导电中性氯化物-碳酸氢盐、氯化物-碘化物和氯化物-甲酸盐交换中发挥着至关重要的作用，每种交换都以 1:1 的化学计量发生。此外，SLC26A4 参与电中性碘化物-碳酸氢盐交换，证明了其在运输必需阴离子方面的多功能性。这些交换的精确化学计量和生电性质强调了转运蛋白在维持细胞离子平衡和调节氯离子和碘离子运动方面的重要性。这些功能使 SLC26A4 成为细胞生理学中的关键参与者，有助于氯离子和碘离子稳态至关重要的多种过程。

Human

E. coli Cell-free

N-6*His

O43511 (M1-S780, H723R)

5172

MAAPGGRSEPPQLPEYSCSYMVSRPVYSELAFQQQHERRLQERKTLRESLAKCCSCSRKRAFGVLKTLVPILEWLPKYRVKEWLLSDVISGVSTGLVATLQGMAYALLAAVPVGYGLYSAFFPILTYFIFGTSRHISVGPFPVVSLMVGSVVLSMAPDEHFLVSSSNGTVLNTTMIDTAARDTARVLIASALTLLVGIIQLIFGGLQIGFIVRYLADPLVGGFTTAAAFQVLVSQLKIVLNVSTKNYNGVLSIIYTLVEIFQNIGDTNLADFTAGLLTIVVCMAVKELNDRFRHKIPVPIPIEVIVTIIATAISYGANLEKNYNAGIVKSIPRGFLPPELPPVSLFSEMLAASFSIAVVAYAIAVSVGKVYATKYDYTIDGNQEFIAFGISNIFSGFFSCFVATTALSRTAVQESTGGKTQVAGIISAAIVMIAILALGKLLEPLQKSVLAAVVIANLKGMFMQLCDIPRLWRQNKIDAVIWVFTCIVSIILGLDLGLLAGLIFGLLTVVLRVQFPSWNGLGSIPSTDIYKSTKNYKNIEEPQGVKILRFSSPIFYGNVDGFKKCIKSTVGFDAIRVYNKRLKALRKIQKLIKSGQLRATKNGIISDAVSTNNAFEPDEDIEDLEELDIPTKEIEIQVDWNSELPVKVNVPKVPIHSLVLDCGAISFLDVVGVRSLRVIVKEFQRIDVNVYFASLQDYVIEKLEQCGFFDDNIRKDTFFLTVRDAILYLQNQVKSQEGQGSILETITLIQDCKDTLELIETELTEEELDVQDEAMRTLAS

86.7 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.