SLC2A9 蛋白, Human (Cell-Free, His)

SLC2A9 Protein, validated by studies, serves as a high-capacity urate transporter in proximal tubules. Additionally, it exhibits residual glucose and fructose transporter activities. Its rapid urate transport (45- to 60-fold faster than glucose) underscores its pivotal role. Notably, it excludes galactose transport and modestly facilitates adenine uptake, contributing to diverse physiological processes. SLC2A9 Protein, Human (Cell-Free, His) is the recombinant human-derived SLC2A9 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of SLC2A9 Protein, Human (Cell-Free, His) is 540 a.a., with molecular weight of 60.2 kDa.

SLC2A9 蛋白作为一种高容量尿酸盐转运蛋白出现，表明其可能参与近端肾小管对尿酸盐的重吸收，这已得到多项研究的支持。这种多功能转运蛋白还可能表现出残留的高亲和力、低容量葡萄糖和果糖转运蛋白活性，从而扩展了其功能库。值得注意的是，SLC2A9 转运尿酸盐的速率明显快于葡萄糖（45 至 60 倍），这突显了其在尿酸盐转运过程中的重要性。有趣的是，它不运输半乳糖，并且可能促进腺嘌呤的适度摄取，同时不参与其他核碱基的运输。因此，这种多面转运蛋白在与尿酸盐以及潜在的葡萄糖和果糖转运相关的多种生理过程中发挥着至关重要的作用。

Human

E. coli Cell-free

N-10*His

Q9NRM0 (M1-P540)

56606

MARKQNRNSKELGLVPLTDDTSHAGPPGPGRALLECDHLRSGVPGGRRRKDWSCSLLVASLAGAFGSSFLYGYNLSVVNAPTPYIKAFYNESWERRHGRPIDPDTLTLLWSVTVSIFAIGGLVGTLIVKMIGKVLGRKHTLLANNGFAISAALLMACSLQAGAFEMLIVGRFIMGIDGGVALSVLPMYLSEISPKEIRGSLGQVTAIFICIGVFTGQLLGLPELLGKESTWPYLFGVIVVPAVVQLLSLPFLPDSPRYLLLEKHNEARAVKAFQTFLGKADVSQEVEEVLAESRVQRSIRLVSVLELLRAPYVRWQVVTVIVTMACYQLCGLNAIWFYTNSIFGKAGIPPAKIPYVTLSTGGIETLAAVFSGLVIEHLGRRPLLIGGFGLMGLFFGTLTITLTLQDHAPWVPYLSIVGILAIIASFCSGPGGIPFILTGEFFQQSQRPAAFIIAGTVNWLSNFAVGLLFPFIQKSLDTYCFLVFATICITGAIYLYFVLPETKNRTYAEISQAFSKRNKAYPPEEKIDSAVTDGKINGRP

60.2 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.