SMIM4 蛋白, Human (Cell-Free, His)

The SMIM4 protein plays a critical role in the assembly and stability of the mitochondrial ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is responsible for oxidative phosphorylation A key component of the mitochondrial electron transport chain (ETC). It mediates early complex III biogenesis, regulating the levels of electron transport chain proteins in response to changing energy demands. SMIM4 Protein, Human (Cell-Free, His) is the recombinant human-derived SMIM4 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of SMIM4 Protein, Human (Cell-Free, His) is 70 a.a., with molecular weight of 11.5 kDa.

SMIM4 对于线粒体泛醇-细胞色素 c 还原酶复合物（也称为复合物 III 或细胞色素 b-c1 复合物）的组装和稳定性至关重要。这种多亚基跨膜复合物在线粒体电子传递链 (ETC) 中发挥着至关重要的作用，而线粒体电子传递链又驱动氧化磷酸化。除了参与复合物 III 的早期生物发生之外，SMIM4 还参与电子传递链蛋白质水平的调节，有助于根据能量需求的变化动态调整能量供应。此外，SMIM4 在细胞色素 c 氧化酶复合物（复合物 IV）组装的初始步骤中发挥作用。它与线粒体核糖体形成关联并与 UQCC6 相互作用，促进 MT-CYB 的合成和膜插入。值得注意的是，SMIM4是COMB（线粒体CYTB生物发生协调子）复合物的关键组成部分，与UQCC1、UQCC2、UQCC4、UQCC5和UQCC6协同作用，调节MT-CYB合成并促进其有效整合到线粒体膜中。

Human

E. coli Cell-free

N-10*His

Q8WVI0 (M1-E70)

440957

MFTRAQVRRILQRVPGKQRFGIYRFLPFFFVLGGTMEWIMIKVRVGQETFYDVYRRKASERQYQRRLEDE

11.5 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.