SPR 蛋白, Human (His)

SPR proteins play a key role in tetrahydrobiopterin biosynthesis by catalyzing the final one or two reductions required to form 5,6,7,8-tetrahydrobiopterin. This enzyme activity is critical for the production of tetrahydrobiopterin, a cofactor involved in various biochemical pathways, including neurotransmitter synthesis and nitric oxide production. SPR Protein, Human (His) is the recombinant human-derived SPR protein, expressed by E. coli , with N-6*His labeled tag. The total length of SPR Protein, Human (His) is 261 a.a., .

沙丙蝶呤还原酶 (SPR) 是一种在四氢生物蝶呤 (BH4) 生物合成中发挥关键作用的酶。具体而言，SPR 催化四氢生物蝶呤生物合成途径中的最后一两次还原，最终形成 5,6,7,8-四氢生物蝶呤。这种辅助因子对于芳香族氨基酸羟化酶的活性至关重要，芳香族氨基酸羟化酶参与神经递质和其他生物活性分子的合成。SPR 的催化活性对于维持适当的四氢生物蝶呤水平至关重要，这反过来又影响各种生理过程的正常功能，包括神经递质的产生。BH4 生物合成失调会影响神经递质稳态，并与某些神经系统疾病有关。参考文献简洁地概述了 SPR 在四氢生物蝶呤生物合成最后步骤中的作用，强调了其在支持关键生化途径中的重要性。

Human

E. coli

N-6*His

P35270 (M1-K261)

6697

Approximately 30 kDa

Greater than 90% as determined by reducing SDS-PAGE.

溶液.

Supplied as a 0.22 μm filtered solution of 50 mM HEPES, 200 mM NaCl, 20% glycerol, 1 mM DTT, pH 7.5.

<1 EU/μg, determined by LAL method.

Please use rapid thawing with running water to thaw the protein.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.