Syntenin-1 蛋白, Human (N-His)

Syntenin-1 protein is known to mediate Syndecan signaling and has a PDZ domain that binds transmembrane proteins. It affects cytoskeletal membrane organization, cell adhesion, protein trafficking, and transcription factor activation. Syntenin-1 Protein, Human (N-His) is the recombinant human-derived Syntenin-1 protein, expressed by E. coli , with N-6*His labeled tag. The total length of Syntenin-1 Protein, Human (N-His) is 298 a.a., with molecular weight of ~32 kDa.

Syntenin-1 蛋白最初被认为是将 Syndecan 介导的信号传导与细胞骨架连接起来的介质，其特征是串联重复的 PDZ 结构域能够结合各种跨膜蛋白的细胞质 C 端结构域。除了在多聚糖信号传导中发挥作用外，syntenin-1 还参与影响细胞骨架膜组织、细胞粘附、蛋白质运输和转录因子的激活。虽然该蛋白主要定位于膜相关的粘附连接和粘着斑，但也存在于内质网和细胞核中。选择性剪接产生编码不同亚型的多个转录变体。此外，在多条染色体上已鉴定出相关的假基因。Syntenin-1 在胎盘 (RPKM 77.0)、胆囊 (RPKM 73.7) 和其他 25 种组织中普遍表达，其广泛存在强调了它参与不同组织的不同细胞过程。

Data is not available.

Human

E. coli

N-6*His

NP_001007068.1 (M1-V298)

6386  [NCBI]

MSLYPSLEDLKVDKVIQAQTAFSANPANPAILSEASAPIPHDGNLYPRLYPELSQYMGLSLNEEEIRANVAVVSGAPLQGQLVARPSSINYMVAPVTGNDVGIRRAEIKQGIREVILCKDQDGKIGLRLKSIDNGIFVQLVQANSPASLVGLRFGDQVLQINGENCAGWSSDKAHKVLKQAFGEKITMTIRDRPFERTITMHKDSTGHVGFIFKNGKITSIVKDSSAARNGLLTEHNICEINGQNVIGLKDSQIADILSTSGTVVTITIMPAFIFEHIIKRMAPSIMKSLMDHTIPEV

Approximately 32 kDa

• 
  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of 50 mM Tris-HCL, 300 mM NaCl, pH 7.4, 5% trehalose, 5% mannitol and 0.01% Tween 80.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US;may vary elsewhere.