Transthyretin/TTR 蛋白, Human (147a.a, HEK293, His)

The transthyretin/TTR protein is a thyroid hormone binder that may be critical for transporting thyroxine from the bloodstream to the brain. Its structure is a homotetramer, forming a dimer of dimers, and its central channel is suggested to play a role in thyroxine binding and transport. Transthyretin/TTR Protein, Human (147a.a, HEK293, His) is the recombinant human-derived Transthyretin/TTR protein, expressed by HEK293 , with C-His labeled tag. The total length of Transthyretin/TTR Protein, Human (147a.a, HEK293, His) is 127 a.a., with molecular weight of ~18.98 kDa.

运甲状腺素蛋白/TTR 蛋白是一种甲状腺激素结合蛋白，可能在将甲状腺素从血液输送到大脑的过程中发挥着至关重要的作用。它形成同四聚体，其结构为二聚体的二聚体，亚基围绕能够容纳两个配体分子的中心通道组装。这表明甲状腺素的结合和运输具有功能意义。此外，运甲状腺素蛋白/TTR 蛋白与 RBP4 相互作用，凸显了甲状腺激素动态调节中潜在的协同作用。同四聚体构型和配体结合特性强调了运甲状腺素蛋白/TTR 在促进甲状腺激素转运和分布方面的重要性，强调了其在维持内分泌平衡中的作用。

1.Measured by its binding ability in a functional ELISA. Immobilized RBP4 at 2.5 μg/mL can bind human TTR. The ED₅₀ for this effect is 960 ng/mL, corresponding to a specific activity is 1.041×10³ Unit/mg.
2.Measured by its binding ability in a functional ELISA.Immobilized recombinant human TTR-His at 10 μg/mL (100 μl/well) can bind recombinant Canine RBP4-Fc with a linear range of 0.3-10.0 μg/mL.

• 
  Measured by its binding ability in a functional ELISA. Immobilized RBP4 at 2.5 μg/mL can bind human TTR. The ED₅₀ for this effect is 960 ng/mL, corresponding to a specific activity is 1.041×10³ Unit/mg.

Human

HEK293

C-His

P02766 (G21-E147)

7276  [NCBI]

GPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE

Approximately 18.98 kDa

• 
  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized a 0.22 μm filtered solution of PBS, pH 7.4 (Normally trehalose is added as protectant before lyophilization. ) or 20 mM PB, 150 mM NaCl, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.