UGT1A7 蛋白, Human (Cell-Free, His)

The UGT1A7 protein is a UDP-glucuronosyltransferase (UGT) that plays a key catalytic role in phase II reactions, conjugating lipophilic substrates with glucuronic acid to enhance water solubility and promote excretion. This enzymatic activity is critical for the elimination of drugs, xenobiotics, and endogenous compounds. UGT1A7 Protein, Human (Cell-Free, His) is the recombinant human-derived UGT1A7 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of UGT1A7 Protein, Human (Cell-Free, His) is 505 a.a., with molecular weight of 60.0 kDa.

UGT1A7 是一种 UDP-葡萄糖醛酸基转移酶 (UGT)，在 II 期生物转化反应中发挥着关键作用，促进亲脂性底物与葡萄糖醛酸的缀合，以增强水溶性并促进排泄到尿液或胆汁中。这种酶活性对于药物、外源性化合物和内源性化合物的消除和解毒至关重要。UGT1A7 参与多种物质的葡萄糖醛酸化，包括内源性雌激素表雌二醇、金雀异黄酮和大豆黄酮等植物雌激素、血管紧张素受体拮抗剂 caderastan 以及抗癌药物伊立替康的活性代谢物 SN-38。此外，它还参与免疫抑制剂霉酚酸酯的生物转化。值得注意的是，虽然 UGT1A7 本身缺乏葡萄糖醛酸化活性，但它可作为异构体 1 的负调节因子。

Human

E. coli Cell-free

N-10*His

Q9HAW7 (G26-H530)

54577

GKLLVVPMDGSHWFTMQSVVEKLILRGHEVVVVMPEVSWQLGRSLNCTVKTYSTSYTLEDQDREFMVFADARWTAPLRSAFSLLTSSSNGIFDLFFSNCRSLFNDRKLVEYLKESCFDAVFLDPFDACGLIVAKYFSLPSVVFARGIFCHYLEEGAQCPAPLSYVPRLLLGFSDAMTFKERVWNHIMHLEEHLFCPYFFKNVLEIASEILQTPVTAYDLYSHTSIWLLRTDFVLEYPKPVMPNMIFIGGINCHQGKPVPMEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH

60.0 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.