UGT1A8 蛋白, Human (Cell-Free, His)

UGT1A8 protein is a key UDP-glucuronosyltransferase (UGT) that plays a vital role in phase II biotransformation by catalyzing the conjugation of lipophilic substrates with glucuronic acid, enhancing water solubility, and promoting excretion. role. UGT1A8 Protein, Human (Cell-Free, His) is the recombinant human-derived UGT1A8 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of UGT1A8 Protein, Human (Cell-Free, His) is 505 a.a., with molecular weight of 59.9 kDa.

UGT1A8 是 UDP-葡萄糖醛酸基转移酶 (UGT) 家族的关键成员，通过催化亲脂性底物与葡萄糖醛酸的结合、增强水溶性并促进排泄到尿液或胆汁中，在 II 期生物转化反应中占据中心地位。这种酶的能力对于药物、外源性化合物和内源性化合物的消除和解毒是不可或缺的。UGT1A8 表现出广泛的底物特异性，将其催化范围扩展到内源性类固醇激素，包括雄激素和雌激素，以及植物雌激素，如染料木黄酮和大豆黄酮，因其抗癌和心血管特性而闻名。值得注意的是，UGT1A8 协调一系列葡萄糖醛酸化步骤，从 DHT 产生二氢睾酮 (DHT) 二葡萄糖醛酸。此外，这种多功能酶有助于 AGTR1 血管紧张素受体拮抗剂 caderastan 的葡萄糖醛酸化，并代谢麦考酚酯（一种免疫抑制剂）。有趣的是，UGT1A8 虽然缺乏葡萄糖醛酸化活性，但可作为异构体 1 的负调节因子，强调其在细胞过程中的复杂作用。

Human

E. coli Cell-free

N-10*His

Q9HAW9 (G26-H530)

54576

GKLLVVPMDGSHWFTMQSVVEKLILRGHEVVVVMPEVSWQLGKSLNCTVKTYSTSYTLEDLDREFMDFADAQWKAQVRSLFSLFLSSSNGFFNLFFSHCRSLFNDRKLVEYLKESSFDAVFLDPFDACGLIVAKYFSLPSVVFARGIACHYLEEGAQCPAPLSYVPRILLGFSDAMTFKERVRNHIMHLEEHLFCQYFSKNALEIASEILQTPVTAYDLYSHTSIWLLRTDFVLDYPKPVMPNMIFIGGINCHQGKPLPMEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH

59.9 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.