YopB 蛋白, Yersinia enterocolitica (Cell-Free, His, SUMO)

YopB, a vital component of the type III secretion system (T3SS), injects bacterial effectors into host cells by forming a membrane pore with YopD. Crucial for virulence, YopB facilitates effector translocation, including YopE, in Yersinia infections. While not directly targeting effectors, YopB may influence the host's immune response. YopB Protein, Yersinia enterocolitica (Cell-Free, His, SUMO) is the recombinant YopB protein, expressed by E. coli Cell-free , with N-6*His, N-SUMO labeled tag. The total length of YopB Protein, Yersinia enterocolitica (Cell-Free, His, SUMO) is 401 a.a., with molecular weight of 57.9 kDa.

YopB 是 III 型分泌系统 (T3SS) 或注射体的重要组成部分，参与将细菌效应蛋白注射到真核宿主细胞中。YopB 与 YopD 一起整合到宿主膜中，形成一个孔，促进效应蛋白易位到靶细胞的细胞质中。这个过程对于细菌的毒力至关重要，因为 YopB 是重要的毒力决定因素。它的作用扩展到 YopE 等特定效应器易位所需，并且对于在小鼠模型系统中建立耶尔森氏菌感染是必不可少的。有趣的是，YopB 在靶向效应子 Yops 中并不发挥直接作用，但可能在远离感染部位的地方影响宿主的免疫反应。

Others

E. coli Cell-free

N-6*His;N-SUMO

P37131 (M1-V401)

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MSALITHDRSTPVTGSLVPYIETPAPAPLQTQQVAGELKDKNGGVSSQGVQLPAPLAVVASQVTEGQQQEITKLLESVTRGTAGSQLISNYVSVLTNFTLASPDTFEIELGKLVSNLEEVRKDIKIADIQRLHEQNMKKIEENQEKIKETEENAKQVKKSGMASKIFGWLIAIASVVIGAIMVASGVGAVAGAMMIASGVIGMANMAVKQAAEDGLISQEAMQVLGPILTAIEVALTVVSTVMTFGGSALKCLADIGAKLGANTASLAAKGAEFSAKVAQISTGISNTVGSAVTKLGGSFGSLTMSHVIRTGSQATQVAVGVGSGITQTINNKKQADLQHNNADLALNKADMAALQSIIDRLKEELSHLSESHRQVMELIFQMINAKGDMLHNLAGRPHTV

57.9 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.