2. Anti-infection Metabolic Enzyme/Protease
  3. SARS-CoV Angiotensin-converting Enzyme (ACE)
  4. Regdanvimab

Regdanvimab  (Synonyms: CT-P59)

目录号: HY-P99346 纯度: 95.00%
COA

摩尔计算器

Regdanvimab (CT-P59) 是一种人单克隆抗体，靶向 SARS-CoV-2 刺突蛋白的受体结合域，阻断与 ACE2 的相互作用以防止病毒进入。Regdanvimab 可用于 COVID-19 的研究。

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Regdanvimab Chemical Structure

Regdanvimab Chemical Structure

CAS No. : 2444308-95-4

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规格 价格 是否有货 数量
1 mg ￥2600
In-stock
5 mg ￥6800
In-stock
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Regdanvimab 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Regdanvimab (CT-P59) is a human monoclonal antibody that targets the receptor-binding domain of SARS-CoV-2 spike protein, blocking interaction with ACE2 for viral entry. Regdanvimab can be used for the research of COVID-19[1].

IC50 & Target

SARS-CoV-2, ACE2[1]
体外研究
(In Vitro)

Regdanvimab (CT-P59) (0-1000 ng/mL; 72 h) 可以中和 Gamma, Delta 和 Epsilon 变体，IC50 在 161.5-1237 ng/mL[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Regdanvimab 相关抗体:
体内研究
(In Vivo)

Regdanvimab (CT-P59) (5-80 mg/kg; i.p.; single dose) 可以降低小鼠 Gamma 和 Delta 株的病毒负担[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: hACE2 transgenic (TG) mice inoculated with Gamma or Delta variant[1]
Dosage: 5, 20, 40, and 80 mg/kg
Administration: Intraperitoneal injection, 8 h post-inoculation, single dose
Result: Delayed body weight loss and showed a statistically significant difference compared to the placebo group. Prevented the weight loss of the mice infected with Delta variant. Significantly inhibited the virus replication in the respiratory tract.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Regdanvimab 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Regdanvimab2444308-95-4CT-P59SARS-CoVAngiotensin-converting Enzyme (ACE)SARS coronavirusCOVID-19Gamma variantDelta variantEpsilon variantInhibitorinhibitorinhibit

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