2. Immunology/Inflammation
  3. Interleukin Related
  4. Reslizumab

Reslizumab  (Synonyms: Sch 55700)

目录号: HY-P9949 纯度: 99.4%
COA

摩尔计算器

Reslizumab (Sch 55700) 是靶向人白介素 5 (IL-5) 的人源化单克隆抗体，用于研究嗜酸性粒细胞性哮喘。Reslizumab 可有效阻断 IL-5 的功能。Reslizumab 对人 IL-5 具有高结合亲和力，在 Biacore 表面等离振子共振和动力学排斥分析中，KD 值分别为 109 pM 和 4.3 pM。

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Reslizumab Chemical Structure

Reslizumab Chemical Structure

CAS No. : 241473-69-8

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1 mg ￥10000
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Reslizumab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Reslizumab (Sch 55700) is humanized monoclonal antibodies that target interleukin-5 (IL-5) for the treatment of eosinophilic asthma. Reslizumab is effective in neutralizing the function of IL-5. Reslizumab has high binding affinity for human IL-5, with KD values of 109 pM and 4.3 pM in the the Biacore surface plasmon resonance and Kinetic Exclusion Assay, respectively[1][2].

IC50 & Target[1][2]

IL-5

91.1 pM (IC50)

体外研究
(In Vitro)

Reslizumab (Sch 55700) (0-10 nM, 48 h) inhibits IL-5-dependent cell proliferation, with an IC50 value of approximately 91.1pM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Reslizumab 相关抗体:

Cell Proliferation Assay[1]

Cell Line: Human erythroleukemic TF-1 cell line
Concentration: 0-10 nM
Incubation Time: 48 h
Result: Showed antiproliferative activity with an IC50 of 91.1 pM.
体内研究
(In Vivo)

Reslizumab (Sch 55700) (0-10 mg/kg; i.p. or i.m.) inhibits pulmonary eosinophilia in a dose-dependent manner in allergic mice[3].
Reslizumab (0.03-30 mg/kg; i.p.) inhibits both the pulmonary eosinophilia and airway hyperresponsiveness, and at 30 mg/kg, i.p. inhibits allergic, but not histamine-induced bronchoconstriction in allergic guinea pigs[3].
Reslizumab (0.1-1 mg/kg; i.p.) blocks the pulmonary eosinophilia and neutrophilia caused by tracheal injection of hIL-5 in guinea pigs[3].
Reslizumab (0.3 mg/kg; i.v.) blocks the pulmonary eosinophilia caused by antigen challenge for up to six months in allergic cynomolgus monkeys[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male B6D2F1/J mice weighing 20−25 g, sensitized by an intraperitoneal injection of 0.5 ml of alum-precipitated antigen (8 µg of ovalbumin (OVA) adsorbed to 2 mg of aluminum hydroxide gel in saline vehicle)[3]
Dosage: 0−10 mg/kg
Administration: Intraperitoneal or intramuscular injection (For studies involving i.p. dose-response and i.m. evaluation, the antibody was given 2 h before OVA challenge. For experiments involving duration of activity, the antibody was given at times of 2 h or 4, 6, 8 or 12 weeks before antigen challenge.)
Result: Inhibited the influx of eosinophils into the lungs for a long time (up to 8 weeks after administration of 10 mg/kg and for up to 4 weeks after administration of 2 mg/kg. Demonstrated an anti-inflammatory activity that was additive to that of oral Prednisolone (HY-17463).
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

瑞替珠单抗
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

纯度: 99.4%

COA (150 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Reslizumab 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Reslizumab241473-69-8Sch 55700瑞替珠单抗Sch55700Sch-55700Interleukin RelatedILeosinophilic asthmapulmonary eosinophiliaairway hyperresponsivenessInhibitorinhibitorinhibit

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