2. Membrane Transporter/Ion Channel Anti-infection Immunology/Inflammation NF-κB Stem Cell/Wnt MAPK/ERK Pathway PI3K/Akt/mTOR
  3. Proton Pump Bacterial COX NF-κB ERK Akt
  4. Revaprazan

Revaprazan (SB 641257) 是可逆性的质子泵 (proton pump) 抑制剂。Revaprazan 能够抑制胃酸分泌并保护胃黏膜。Revaprazan 可以抑制 IkappaB-α 降解以及 Akt 失活，从而减弱幽门螺杆菌 (H. pylori) 诱导的 COX-2 表达。Revaprazan 可用于感染和炎症相关的研究，例如幽门螺杆菌 (H. pylori) 感染引发的胃炎和胃溃疡。

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Revaprazan

Revaprazan Chemical Structure

CAS No. : 199463-33-7

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Revaprazan 的其他形式现货产品:

Customer Review

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Revaprazan 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

查看 COX 亚型特异性产品:

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COX COX-1 COX-2 COX-3

查看 NF-κB 亚型特异性产品:

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

查看 ERK 亚型特异性产品:

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ERK ERK1 ERK2 ERK5 ERK8

查看 Akt 亚型特异性产品:

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Akt Akt1 Akt2 Akt3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Revaprazan (SB 641257) is reversible proton pump inhibitor. Revaprazan can inhibit gastric acid secretion and protect gastric mucosa. Revaprazan can inhibit IkappaB-alpha degradation as well as Akt inactivation, resulting in attenuation of H. pylori-induced COX-2 expression. Revaprazan can be used for the researches of infection and inflammmation, such as H. pylori-infected gastric inflammation and gastric ulcer[1][2].

IC50 & Target[1]

COX-2

 

体外研究
(In Vitro)

Revaprazan (5-20 μM, 24 h) 可降低幽门螺杆菌 (H. pylori) 刺激的 AGS 细胞中 COX-2 的表达和活性[1]。
Revaprazan (5-20 μM, 24 h) 可抑制幽门螺杆菌 (H. pylori) 刺激的 AGS 细胞中 NF-κB 的转录活性[1]。
Revaprazan (5-20 μM, 24 h) 可改善幽门螺杆菌 (H. pylori) 刺激的 AGS 细胞生长迟缓的情况[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Revaprazan 相关抗体:

Western Blot Analysis[1]

Cell Line: H. pylori-stimulated AGS cells
Concentration: 5 and 20 μM
Incubation Time: 24 h
Result: Reduced COX-2 expression.
Inhibited transcription activity of NF-κB.
Inactivated ERK and Akt phosphorylation.
Clinical Trial
分子量

362.44

Formula

C22H23FN4
CAS 号
中文名称

瑞伐拉赞
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Revaprazan 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Revaprazan199463-33-7SB 641257瑞伐拉赞SB641257SB-641257Proton PumpBacterialCOXNF-κBERKAktCyclooxygenaseNuclear factor-κBNuclear factor-kappaBExtracellular signal regulated kinasesPKBProtein kinase BProton pumpGastric acidGastric mucosaAGSCOX-2H. pyloriGastric inflammationInhibitorinhibitorinhibit

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