2. Cytoskeleton
  3. Integrin
  4. RGD-4C

RGD-4C 是一种具有整合素结合活性的精氨酸-甘氨酸-天冬氨酸肽 (ACDCRGDCFC)。Arg-Gly-Asp (RGD) 序列是细胞外基质蛋白的主要整合素识别位点，含有该序列的多肽可以模拟基质蛋白的识别特异性。RGD-4C 是 αv 整合素配体，可与生物活性分子偶联，在动物模型中发挥抗肿瘤作用。

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Custom Peptide Synthesis

RGD-4C Chemical Structure

RGD-4C Chemical Structure

CAS No. : 332179-76-7

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3.  试用装只面向终端客户。

规格 价格 是否有货 数量
1 mg ￥850
In-stock
5 mg ￥2200
In-stock
10 mg ￥3500
In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Customer Review

RGD-4C 相关抗体

Top Publications Citing Use of Products

查看 Integrin 亚型特异性产品:

查看所有亚型
αvβ1 αvβ3 αvβ5 αvβ6 αvβ8 α5β1 α1β1 α2β1 α4β1 α9β1 αIIbβ3 α4β7 αLβ2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

RGD-4C is a arginine-glycine-aspartic acid peptide (ACDCRGDCFC) with integrin binding activity. The Arg-Gly-Asp (RGD) sequence serves as the primary integrin recognition site in extracellular matrix proteins, and peptides containing this sequence can mimic the recognition specificity of the matrix proteins. RGD-4C is a αv-integrin ligand, can conjugate with bioactive molecule to exert antitumor effects in animal models[1][2][3].

体外研究
(In Vitro)

RGD-4C (2.5, 5, 10 μg/mL) inhibits BAE cell proliferation by synthetic form modified with endostatin-derived peptides[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

RGD-4C 相关抗体:
体内研究
(In Vivo)

RGD-4C (9.11 mg/kg; injection; single dose) inhibits the growth of B16F10 mouse melanoma in vivo[2].
Modified RGD-4C fused with the N-terminus of plant-derived single-chain ribosome inactivating protein saporin (SAP) (called RGD-SAP), (diluted in sodium chloride, 0.9%; i.v.; 200 µL; every 5 days, for 3 times) exerts anti-tumor activity in a model of muscle invasive bladder cancer[3].
RGD-SAP in combination with mitomycin C, a chemotherapeutic drug, increases the survival of mice bearing orthotopic bladder cancer with no evidence of systemic toxicity[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1145.27

Formula

C42H60N14O16S4
CAS 号
性状

固体

颜色

White to off-white

Sequence Shortening

ACDCRGDCFCG(Disulfide bridge: Cys2-Cys10; Cys4-Cys8)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : 25 mg/mL (21.83 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.8732 mL 4.3658 mL 8.7316 mL
5 mM 0.1746 mL 0.8732 mL 1.7463 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

RGD-4C 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.8732 mL 4.3658 mL 8.7316 mL 21.8289 mL
5 mM 0.1746 mL 0.8732 mL 1.7463 mL 4.3658 mL
10 mM 0.0873 mL 0.4366 mL 0.8732 mL 2.1829 mL
15 mM 0.0582 mL 0.2911 mL 0.5821 mL 1.4553 mL
20 mM 0.0437 mL 0.2183 mL 0.4366 mL 1.0914 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RGD-4C332179-76-7Integrinrginine-glycine-aspartic acid peptideintegrin binding activityrecognition specificitymatrix proteinInhibitorinhibitorinhibit

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