1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. nAChR
  3. (S)-UFR2709 hydrochloride

(S)-UFR2709 hydrochloride 

目录号: HY-137231B
产品使用指南

(S)-UFR2709 (hydrochloride) 是一种竞争性的 nAChR 拮抗剂,并显示出较强的亲和力,对 α4β2 nAChR 的亲和力比对 α7 nAChR 的高。(S)-UFR2709 (hydrochloride) 在偏好酒精的老鼠中减少焦虑,并且可以减少其酒精摄入和对酒精偏好。(S)-UFR2709 (hydrochloride) 是抗焦虑试剂,可用于研究尼古丁成瘾。

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(S)-UFR2709 hydrochloride Chemical Structure

(S)-UFR2709 hydrochloride Chemical Structure

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Description

(S)-UFR2709 (hydrochloride) is a competitive nAChR antagonist and displays higher affinity for α4β2 nAChRs than for α7 nAChRs. (S)-UFR2709 (hydrochloride) decreases anxiety and reduces ethanol consumption and ethanol preference in alcohol-preferring rats. (S)-UFR2709 (hydrochloride) acts as an anxiolytic agent and can be used for the study of nicotine addiction[1][2].

In Vitro

Brain nicotinic acetylcholine receptors (nAChRs) is a heterogeneous family of pentameric acetylcholine-gated cation channels, which is a molecular target for the treatment of alcohol abuse and dependence[1].

In Vivo

(S)-UFR2709 (hydrochloride) (50-100 μg/ml; 3 min and then maintained for another 5 min in a holding tank before testing the swimming behaviour in the test tank for a period of 5 min) produces a decrease in the bottom dwelling for NTT test, and UFR2709 induces a significant and dose-dependent decrease in bottom dwelling time to 52.9 and 87.0 s, respectively at 50 and 100 μg/ml[2].
(S)-UFR2709 (hydrochloride) (50-100 μg/ml) decreases nicotine-evoked mRNA expression of α4 nACh receptor subunit, but UFR2709 has less effect on α4 nACh receptor subunit in the brain of adult zebrafish[2].
(S)-UFR2709 (hydrochloride) (intraperitoneal injection; 1-10 mg/kg; daily; 17 days) reduces ethanol consumption and ethanol preference and increased water consumption in a dose-dependent manner. The most effective dose of UFR2709 is 2.5 mg/kg, it induces a 56% reduction in alcohol consumption. (S)-UFR2709 (hydrochloride) does not affect the weight or locomotor activity of the rats[1].

Animal Model: High-alcohol-drinking UChB rats[1]
Dosage: 10 mg/kg, 5 mg/kg, 2.5 mg/kg, or 1 mg/kg
Administration: Intraperitoneal injection; 1-10 mg/kg; daily; 17 days
Result: Did not affect the weight or locomotor activity and reduced ethanol consumption and preference.
Molecular Weight

255.74

Formula

C₁₃H₁₈ClNO₂

SMILES

O=C(C1=CC=CC=C1)OC[C@H](CCC2)N2C.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

(S)-UFR2709nAChRNicotinic acetylcholine receptorsbehaviouralparadigmconditioned place preferenceanxietyrewardInhibitorinhibitorinhibit

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产品名称:
(S)-UFR2709 hydrochloride
目录号:
HY-137231B
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