1. GPCR/G Protein
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  3. Saralasin acetate hydrate

Saralasin acetate hydrate  (Synonyms: [Sar1,Ala8] Angiotensin II acetate hydrate)

目录号: HY-P0205A
产品使用指南

Saralasin ([Sar1,Ala8] Angiotensin II) acetate hydrate 是血管紧张素 II (angiotensin II) 的八肽类似物。Saralasin acetate 是一种竞争性的血管紧张素 II 受体 (angiotensin II receptor) 拮抗剂,Ki 值为 0.32 nM (74% 的结合位点),并具有部分激动剂活性。Saralasin acetate 可用于肾血管性高血压、肾素依赖性(血管紧张素原性)高血压的相关研究。

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Custom Peptide Synthesis

Saralasin acetate hydrate Chemical Structure

Saralasin acetate hydrate Chemical Structure

CAS No. : 39698-78-7

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生物活性

Saralasin ([Sar1,Ala8] Angiotensin II) acetate hydrate is an octapeptide analog of angiotensin II. Saralasin acetate hydrate is a competitive angiotensin II receptor antagonist with a Ki value of 0.32 nM for 74% of the binding sites, and has partial agonist activity as well. Saralasin acetate hydrate can be used for the research of renovascular hypertension, renin-dependent (angiotensinogenic) hypertension[1][3][6].

IC50 & Target

Ki: 0.32 nM (Angiotensin II receptor)[3]

体外研究
(In Vitro)

Saralasin acetate hydrate (1 nM, 48 or 72 h) inhibits cell growth in 3T3 and SV3T3 cells[1].
Saralasin acetate hydrate (5 μM, 2h) restores Ito, fast (Fast-Inactivating Transient Outward K+ Current in Mouse Ventricle) and I K, slow (Slow-Inactivating Transient Outward K+ Current in Mouse Ventricl) to control levels in myocytes[2].
Saralasin acetate hydrate (0.1-10 nM, 40 min) inhibits binding of FITC-Ang II to rat liver membrane preparation (used as the source of angiotensin receptors) with a Ki value of 0.32 nM for 74% of the binding sites and 2.7 nM for the remaining binding sites[3].
Saralasin acetate hydrate (1 μM, perfused rat ovary in vitro) inhibits the ovulation rate versus control and reduces prostaglandin E2 and 6-keto-prostaglandin F levels[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: 3T3 and SV3T3 cells
Concentration: 1 nM
Incubation Time: 48 h, 72 h
Result: Inhibited cell growth in 3T3 and SV3T3 cells and caused an increase of cellular renin concentration.
体内研究
(In Vivo)

Saralasin acetate hydrate (intravenous injection, 5-50 μg/kg, a single dose) ameliorates the oxidative stress and tissue injury in cerulein-induced pancreatitis[5].
Saralasin acetate hydrate (subcutaneous injection, 10 and 30 mg/kg, a single dose) increases serum renin activity (SRA) in normal, conscious rats, without markedly altering blood pressure or heart rate[6].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Cerulein-induced acute pancreatitis rats model[5]
Dosage: 5, 10, 20, and 50 μg/kg, a single dose.
Administration: Intravenous injection
Result: Restored the pancreatic morphological characteristics to the control level.
Reduced pancreatic injury and suppressed the glutathione depletion induced by cerulean.
Animal Model: Male Sprague-Dawley rats[6]
Dosage: 10 and 30 mg/kg, a single dose.
Administration: Subcutaneous injection
Result: Stimulated renin release without altering blood pressure or heart rate at the time of measuring serum renin levels 20 minutes after injection.
Formula

C44H71N13O13

CAS 号
Sequence Shortening

{Sar}-RVYVHPA

中文名称

沙拉新醋酸水合物;肌丙抗增压素醋酸水合物

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

Saralasin acetate hydrate 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Saralasin acetate hydrate
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