2. GPCR/G Protein
  3. Angiotensin Receptor
  4. Saralasin

Saralasin  (Synonyms: [Sar1,Ala8] Angiotensin II)

目录号: HY-P0205 纯度: 98.71%
COA 产品使用指南 技术支持

Saralasin ([Sar1,Ala8] Angiotensin II) 是血管紧张素 II (angiotensin II) 的八肽类似物。Saralasin 是一种竞争性的血管紧张素 II 受体 (angiotensin II receptor) 拮抗剂，Ki 值为 0.32 nM (74% 的结合位点)，并具有部分激动剂活性。Saralasin 可用于肾血管性高血压、肾素依赖性（血管紧张素原性）高血压的相关研究。

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Custom Peptide Synthesis

Saralasin

Saralasin Chemical Structure

CAS No. : 34273-10-4

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5 mg ￥1000
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10 mg ￥1700
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25 mg ￥3400
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50 mg ￥5100
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Customer Review

Other Forms of Saralasin:

Saralasin 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Saralasin ([Sar1,Ala8] Angiotensin II) is an octapeptide analog of angiotensin II. Saralasin is a competitive angiotensin II receptor antagonist with a Ki value of 0.32 nM for 74% of the binding sites, and has partial agonist activity as well. Saralasin can be used for the research of renovascular hypertension, renin-dependent (angiotensinogenic) hypertension[1][3][6].

IC50 & Target

Ki: 0.32 nM (Angiotensin II receptor)[3]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEK293 IC50
4 x 10-10 M
Compound: Saralasin
Displacement of [125I][Sar1,Ile8]-AT2 from human recombinant AT1 receptor expressed in HEK293 cells measured after 120 mins by scintillation counting method
Displacement of [125I][Sar1,Ile8]-AT2 from human recombinant AT1 receptor expressed in HEK293 cells measured after 120 mins by scintillation counting method
[PMID: 27876250]
体外研究
(In Vitro)

Saralasin (1 nM, 48 or 72 h) inhibits cell growth in 3T3 and SV3T3 cells[1].
Saralasin (5 μM, 2h) restores Ito, fast (Fast-Inactivating Transient Outward K+ Current in Mouse Ventricle) and I K, slow (Slow-Inactivating Transient Outward K+ Current in Mouse Ventricl) to control levels in myocytes[2].
Saralasin (0.1-10 nM, 40 min) inhibits binding of FITC-Ang II to rat liver membrane preparation (used as the source of angiotensin receptors) with a Ki value of 0.32 nM for 74% of the binding sites and 2.7 nM for the remaining binding sites[3].
Saralasin (1 μM, perfused rat ovary in vitro) inhibits the ovulation rate versus control and reduces prostaglandin E2 and 6-keto-prostaglandin F1α levels[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Saralasin 相关抗体:

Cell Proliferation Assay[1]

Cell Line: 3T3 and SV3T3 cells
Concentration: 1 nM
Incubation Time: 48 h, 72 h
Result: Inhibited cell growth in 3T3 and SV3T3 cells and caused an increase of cellular renin concentration.
体内研究
(In Vivo)

Saralasin (intravenous injection, 5-50 μg/kg, a single dose) ameliorates the oxidative stress and tissue injury in cerulein-induced pancreatitis[5].
Saralasin (subcutaneous injection, 10 and 30 mg/kg, a single dose) increases serum renin activity (SRA) in normal, conscious rats, without markedly altering blood pressure or heart rate[6].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Cerulein-induced acute pancreatitis rats model[5]
Dosage: 5, 10, 20, and 50 μg/kg, a single dose.
Administration: Intravenous injection
Result: Restored the pancreatic morphological characteristics to the control level.
Reduced pancreatic injury and suppressed the glutathione depletion induced by cerulean.
Animal Model: Male Sprague-Dawley rats[6]
Dosage: 10 and 30 mg/kg, a single dose.
Administration: Subcutaneous injection
Result: Stimulated renin release without altering blood pressure or heart rate at the time of measuring serum renin levels 20 minutes after injection.
分子量

912.05

Formula

C42H65N13O10
CAS 号
性状

固体

颜色

White to off-white

Sequence

{Sar}-Arg-Val-Tyr-Val-His-Pro-Ala
Sequence Shortening

{Sar}-RVYVHPA
中文名称

沙拉新；肌丙抗增压素
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 50 mg/mL (54.82 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.0964 mL 5.4822 mL 10.9643 mL
5 mM 0.2193 mL 1.0964 mL 2.1929 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 98.71%

COA (288 KB) RP-HPLC (110 KB) MS (207 KB)

产品使用指南 (1538 KB)
参考文献

Saralasin 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.0964 mL 5.4822 mL 10.9643 mL 27.4108 mL
5 mM 0.2193 mL 1.0964 mL 2.1929 mL 5.4822 mL
10 mM 0.1096 mL 0.5482 mL 1.0964 mL 2.7411 mL
15 mM 0.0731 mL 0.3655 mL 0.7310 mL 1.8274 mL
20 mM 0.0548 mL 0.2741 mL 0.5482 mL 1.3705 mL
25 mM 0.0439 mL 0.2193 mL 0.4386 mL 1.0964 mL
30 mM 0.0365 mL 0.1827 mL 0.3655 mL 0.9137 mL
40 mM 0.0274 mL 0.1371 mL 0.2741 mL 0.6853 mL
50 mM 0.0219 mL 0.1096 mL 0.2193 mL 0.5482 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Saralasin34273-10-4[Sar1,Ala8] Angiotensin II沙拉新肌丙抗增压素Angiotensin ReceptorHypertensionangiotensinFITC-Angiotensinovulationovarian perfusionoxidative stressreninprostaglandinInhibitorinhibitorinhibit

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