1. GPCR/G Protein Neuronal Signaling Membrane Transporter/Ion Channel
  2. Dopamine Receptor 5-HT Receptor Potassium Channel
  3. SCH-23390 maleate

SCH-23390 maleate  (Synonyms: R-(+)-SCH-23390 maleate)

目录号: HY-108400
产品使用指南

SCH-23390 maleate (R-(+)-SCH-23390 maleate) 是一种有效的选择性的多巴胺 D1 样受体拮抗剂,其对 D1D5 受体的 Ki 分别为 0.2 nM 和 0.3 nM。SCH-23390 maleate 也是一种有效的人 5-HT2C 受体激动剂,Ki 为 9.3 nM。SCH-23390 maleate 与 5-HT25-HT1C 受体具有高亲和力。SCH-23390 maleate 还抑制 G 蛋白偶联的内向整流钾 (GIRK) 通道,IC50 为 268 nM。

MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

SCH-23390 maleate Chemical Structure

SCH-23390 maleate Chemical Structure

CAS No. : 87134-87-0

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

SCH-23390 maleate 的其他形式现货产品:

Customer Review

Other Forms of SCH-23390 maleate:

注册 MCE会员完成审核
即刻享有 积分商城 300 专属积分

Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SCH-23390 maleate (R-(+)-SCH-23390 maleate) is a potent and selective dopamine D1-like receptor antagonist with Kis of 0.2 nM and 0.3 nM for the D1 and D5 receptor, respectively. SCH-23390 maleate is a potent and high efficacy human 5-HT2C receptor agonist with a Ki of 9.3 nM. SCH-23390 maleate also binds with high affinity to the 5-HT2 and 5-HT1C receptors. SCH-23390 maleate inhibits G protein-coupled inwardly rectifying potassium (GIRK) channels with an IC50 of 268 nM[1][2][3].

IC50 & Target[1][2][3]

D1 Receptor

0.2 nM (Ki)

D5 Receptor

0.3 nM (Ki)

5-HT2C Receptor

9.3 nM (Ki)

GIRK

268 nM (IC50)

体外研究
(In Vitro)

SCH-23390 (1 μM) treatment reverses the inhibitory effects of Isosibiricin on NLRP3 expression and the cleavages of caspase-1 and IL-1β in the LPS-induced BV-2 cells. SCH-23390 could reverse the Isosibiricin-mediated inhibition of the NLRP3/caspase-1 inflammasome pathway[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

SCH-23390 can abolish generalized seizures evoked by the chemoconvulsants: pilocarpine and soman. SCH-23390 has also been used in studies of other neurological disorders in which the dopamine system has been implicated, such as psychosis and Parkinson's disease. Apart from the study of neurological disorders, SCH-23390 has been extensively used as a tool in the topographical determination of brain D1 receptors in rodents, nonhuman primates, and humans[1].
SCH-23390 is a very short-acting compound with an elimination half-life of around 25 min following administration of 0.3 mg/kg i.p. in the rat[1].
SCH-23390 augments dopamine-induced ductus constriction in CD-1 mouse vessels under newborn O2 conditions[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

403.86

Formula

C21H22ClNO5

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称:

 

* 需求量:

* 客户姓名:

 

* Email:

* 电话:

 

* 公司或机构名称:

   留言给我们:

Bulk Inquiry

Inquiry Information

产品名称:
SCH-23390 maleate
目录号:
HY-108400
需求量: