2. Protein Tyrosine Kinase/RTK Apoptosis Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Src Apoptosis Reactive Oxygen Species (ROS)
  4. Scr-IN-2

Scr-IN-2 是一种有效的 c-Scr 抑制剂，其 IC50 为 302 nM。Scr-IN-2 表现出纳摩尔级抗乳腺癌活性。Scr-IN-2 可升高细胞 ROS 水平，诱导线粒体损伤、G1期阻滞和细胞凋亡 (apoptosis)。Scr-IN-2 可用于乳腺癌的研究。

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Scr-IN-2

Scr-IN-2 Chemical Structure

CAS No. : 2787582-78-7

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Scr-IN-2 相关抗体

Top Publications Citing Use of Products

查看 Src 亚型特异性产品:

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Lck Fyn Blk Hck Lyn Yes SRC-3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Scr-IN-2 is an effective c-Scr inhibitor with an IC50 of 302 nM. Scr-IN-2 exhibits nanomolar-level anti-breast cancer activity. Scr-IN-2 increases the level of ROS in cells, induces mitochondrial damage, G1 phase arrest, and apoptosis. Scr-IN-2 can be used in the research of breast cancer[1].

体外研究
(In Vitro)

Scr-IN-2 (Compound 3g) 能够抑制 MDAMB-231、T47D 和 MCF-7 细胞的增殖，其 IC50 分别为 0.812、1.03 和 0.568 μM，并且对正常乳腺细胞 (MCF-10A) 无明显毒性[1]。
Scr-IN-20 (500 nM, 48 h) 会增加活性氧 (ROS) 的生成，对线粒体造成损害，诱导细胞凋亡，并使 MCF-7 细胞的细胞周期停滞在 G1 期[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Scr-IN-2 相关抗体:

Apoptosis Analysis[1]

Cell Line: MCF-7 cells
Concentration: 500 nM
Incubation Time: 48 h
Result: Reached the proportion of apoptotic cells by 62.5%.

Cell Cycle Analysis[1]

Cell Line: MCF-7 cells
Concentration: 500 nM
Incubation Time: 48 h
Result: Blocked MCF-7 cells in the G1 phase to inhibit DNA replication and cell proliferation.
分子量

383.53

Formula

C21H33N7
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Scr-IN-2 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Scr-IN-22787582-78-7SrcApoptosisReactive Oxygen Species (ROS)Breast cancerAnticancerKinasesDrug discoveryCell deathMolecular modelingInhibitorinhibitorinhibit

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