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coactivator

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By Targets:	PGC-1α (6) Adiponectin Receptor (1) AMPK (1) Apoptosis (3) Aryl Hydrocarbon Receptor (1) Autophagy (4) Constitutive Androstane Receptor (1) Cytochrome P450 (2) Drug Isomer (1) Endogenous Metabolite (2) Estrogen Receptor/ERR (2) Ferroptosis (1) GABA Receptor (1) Histone Acetyltransferase (1) Histone Methyltransferase (9) Interleukin Related (1) Isotope-Labeled Compounds (1) LXR (1) Mineralocorticoid Receptor (1) Orphan Receptor (1) Paraptosis (2) Poly(ADP-ribose) Glycohydrolase (PARG) (1) PPAR (3) Pregnane X Receptor (PXR) (1) Progesterone Receptor (1) Prostaglandin Receptor (1) PROTACs (2) RAR/RXR (1) Reactive Oxygen Species (ROS) (2) Salt-inducible Kinase (SIK) (1) Sirtuin (1) Src (4) Thyroid Hormone Receptor (3) TNF Receptor (1) VD/VDR (4) YAP (2)
By Research Areas:	Cancer (22) Cardiovascular Disease (1) Endocrinology (3) Infection (1) Inflammation/Immunology (2) Metabolic Disease (18)

By Targets:

PGC-1α (6)

Adiponectin Receptor (1)

AMPK (1)

Apoptosis (3)

Aryl Hydrocarbon Receptor (1)

Autophagy (4)

Constitutive Androstane Receptor (1)

Cytochrome P450 (2)

Drug Isomer (1)

Endogenous Metabolite (2)

Estrogen Receptor/ERR (2)

Ferroptosis (1)

GABA Receptor (1)

Histone Acetyltransferase (1)

Histone Methyltransferase (9)

Interleukin Related (1)

Isotope-Labeled Compounds (1)

LXR (1)

Mineralocorticoid Receptor (1)

Orphan Receptor (1)

Paraptosis (2)

Poly(ADP-ribose) Glycohydrolase (PARG) (1)

PPAR (3)

Pregnane X Receptor (PXR) (1)

Progesterone Receptor (1)

Prostaglandin Receptor (1)

PROTACs (2)

RAR/RXR (1)

Reactive Oxygen Species (ROS) (2)

Salt-inducible Kinase (SIK) (1)

Sirtuin (1)

Src (4)

Thyroid Hormone Receptor (3)

TNF Receptor (1)

VD/VDR (4)

YAP (2)

By Research Areas:

Cancer (22)

Cardiovascular Disease (1)

Endocrinology (3)

Infection (1)

Inflammation/Immunology (2)

Metabolic Disease (18)

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Targets Recommended: PGC-1α

Cat. No.	Product Name	Target	Research Area	Chemical Structure

HY-15214A

CARM1-IN-3 dihydrochloride	Histone Methyltransferase	Cancer
CARM1-IN-3 dihydrochloride (compound 17b) 是一种有效的选择性辅助激活因子相关精氨酸甲基转移酶 co-activator associated argininemethyltransferase (CARM1) 抑制剂，IC₅₀ 值为 0.07 µM 。

HY-15214

CARM1-IN-3	Histone Methyltransferase	Cancer
CARM1-IN-3 (compound 17b) 是一种有效的选择性辅助激活因子相关精氨酸甲基转移酶 co-activator associated argininemethyltransferase (CARM1) 抑制剂，IC₅₀ 值为 0.07 µM 。

HY-12397

ZK159222 1 篇文献验证	VD/VDR	Endocrinology
ZK159222 是 1α,25-(OH)2D3 的类似物，是有效的 1α,25-(OH)2D3 受体 (VDR) 拮抗剂。ZK159222 拮抗作用的机制是由配体诱导的维生素 D 受体与辅助激活剂的相互作用缺乏所介导的。ZK159222 具有部分激动性。

HY-17538

ZLN005 35 篇以上引用文献	PGC-1α Autophagy	Metabolic Disease
ZLN005 是新型过氧化物增殖激活受体协同激活子 (PGC-1α) 激活剂。

HY-17538S

ZLN005-d4	PGC-1α Autophagy	Metabolic Disease
ZLN005-d₄ 是 ZLN005 氘代物。ZLN005 是新型过氧化物增殖激活受体协同激活子 (PGC-1α) 激活剂。

HY-101491

SR-18292 最多引用文献 51 篇文献验证	PGC-1α Autophagy	Metabolic Disease
SR-18292 是一种 PPARγ 共激活因子-1α (PGC-1α) 抑制剂，可促进 PGC-1α 乙酰化，抑制糖异生基因的表达，并减少肝细胞中葡萄糖的产生。

HY-156153

CARM1 degrader-2	Histone Methyltransferase	Cancer
CARM1 degrader-2 (compound 3e) 是辅助激活因子相关精氨酸甲基转移酶 co-activator associated argininemethyltransferase (CARM1) 的降解剂 (DC₅₀=8.8 nM)。CARM1 degrader-2 以 VHL 和蛋白酶体依赖性方式降解 CARM1。由此，CARM1 degrader-2 可抑制 CARM1 底物 (如聚腺苷酸结合蛋白 PABP1 和 BGR1 相关因子 BAF155) 甲基化并抑制乳腺癌细胞迁移。

HY-156152

CARM1 degrader-1	Histone Methyltransferase	Cancer
CARM1 degrader-1 (compound 3b) 是辅助激活因子相关精氨酸甲基转移酶 co-activator associated argininemethyltransferase (CARM1) 的降解剂 (DC₅₀=8.1 nM)。CARM1 degrader-1 以 VHL 和蛋白酶体依赖性方式降解 CARM1。由此，CARM1 degrader-1 可抑制 CARM1 底物 (如聚腺苷酸结合蛋白 PABP1 和 BGR1 相关因子 BAF155) 甲基化并抑制乳腺癌细胞迁移。

HY-P2515

Transcriptional Intermediary Factor 2 (TIF2) (740-753)	Histone Acetyltransferase	Others
Transcriptional Intermediary Factor 2 (TIF2) (740-753) 是转录中介因子 2 (TIF2) 的共激活肽，由 TIF-2 蛋白的 14 个氨基酸残基 (⁷⁴⁰KENALLRYLLDKDD⁷⁵³) 组成。

HY-P5458

SRC-1 (686-700)	Mineralocorticoid Receptor	Others
SRC-1 (686-700) 是一种有生物活性的肽。(该肽是氨基酸 686 至 700 的片段，包含第二个 LXXLL 基序，源自类固醇受体共激活剂 (SRC1) 的 NR 盒 II。共激活蛋白以配体依赖性方式与核受体相互作用并增强转录。)

HY-112920

TM-25659	YAP	Metabolic Disease
TM-25659是具有PDZ结合基序的转录共激活子 (TAZ) 的调制剂。抗骨质疏松和抗肥胖活性。

HY-101491S

SR-18292-d9	Isotope-Labeled Compounds PGC-1α Autophagy	Metabolic Disease
SR-18292-d₉ 是一种 SR-18292 (HY-101491) 的氘代物。SR-18292 是一种 PPARγ 共激活因子-1α (PGC-1α) 抑制剂，可促进 PGC-1α 乙酰化，抑制糖异生基因的表达，并减少肝细胞中葡萄糖的产生。

HY-113960

ERRα antagonist-1	Estrogen Receptor/ERR	Cancer
ERRα antagonist-1 (Compound A) 是一种选择性的，高亲和力的雌激素相关受体α (ERRα) 拮抗剂。ERRα antagonist-1 抑制 ERRα 与增殖物激活的受体γ共激活因子 1α (PGC-1α) 和 PGC-1β 的相互作用，IC₅₀ 值分别为 170 nM 和 180 nM。

HY-19625

MCB-613	Reactive Oxygen Species (ROS) Paraptosis	Cancer
MCB-613 是一种有效的类固醇受体共激活因子 (SRC) 小分子“刺激物” (SMS)，超刺激 SRCs 的转录活性。 MCB-613 增加了 SRC 与其他共激活因子的相互作用，并显着诱导 ER 应激与活性氧 (ROS) 的产生相结合。 MCB-613 是一种 SMS，通过过度刺激 SRC 致癌程序，靶向癌基因用作抗癌活性分子。

HY-101447

SI-2 EPH 116	Src Apoptosis	Cancer
SI-2 (EPH 116) 是类固醇受体辅激活剂 3 (SRC-3) 的抑制剂，可降低细胞中 SRC-3 的转录活性和蛋白质水平，对癌细胞具有细胞毒性，可抑制 MDA-MB-468 的迁移，诱导 MDA-MB-468 细胞凋亡 (apoptosis)。SI-2 可抑制小鼠模型中的肿瘤生长，且对心脏和其他主要器官无明显毒性（20 mg/kg）。

HY-122041

Ethacridine	Apoptosis Poly(ADP-ribose) Glycohydrolase (PARG)	Cancer
Ethacridine 是一种聚 (ADP-核糖) 糖水解酶 (PARG) 的抑制剂，也是转录共激活因子的激活剂。Ethacridine 诱导甲状腺癌细胞凋亡 (apoptosis)，促进甲状腺滤泡细胞分化。

HY-117927

EPZ0025654 GSK3536023	Histone Methyltransferase	Cancer
EPZ0025654 (GSK3536023) 是蛋白质精氨酸甲基转移酶 4 (PRMT4) (也称为辅激活剂相关精氨酸甲基转移酶 1 CARM1) 的抑制剂，IC₅₀ 为 3 nM。

HY-125787

MLS000389544	Thyroid Hormone Receptor	Metabolic Disease
MLS000389544 是一种选择性有效甲基磺酰基硝基苯甲酸甲状腺激素受体 β (TRβ) 拮抗剂，可阻断 TRβ 与类固醇受体辅激活因子 2 (SRC2) 的结合。

HY-146288

LXR agonist 2	LXR	Metabolic Disease
LXR agonist 2 (compound 18rr) 是一种有效的 LXR (肝 X 受体)激动剂。LXR agonist 2 可以稳定 NCOA1 (助激活剂)，导致 LXR 激动。

HY-17538A

ZLN005 hydrochloride	PGC-1α	Metabolic Disease
ZLN005 (hydrochloride) 是一种过氧化物酶体增殖激活受体-g 辅激活因子-1a (PGC-1α) 激活剂。ZLN005 (hydrochloride) 可刺激骨骼肌细胞中 PGC-1α 和下游基因的表达，改善葡萄糖利用和脂肪酸氧化。ZLN005 (hydrochloride) 可增加糖尿病 db/db 小鼠骨骼肌中 PGC-1α 和下游基因的转录，增加脂肪氧化并改善葡萄糖耐量、丙酮酸耐受性和胰岛素敏感性。

HY-121582

(E)-SI-2 (E)-EPH 116	Drug Isomer	Cancer
(E)-SI-2 是 SI-2，一种类固醇受体辅激活因子 SRC-3 抑制剂的异构体。SI-2 具有抗癌活性，可增加乳腺癌小鼠中细胞毒性免疫细胞的数量。

HY-100565

SGC2085 1 篇文献验证	Histone Methyltransferase	Cancer
SGC2085 是一种靶向共激活剂相关精氨酸甲基转移酶 1 (CARM1) 的选择性抑制剂，IC₅₀ 为 50 nM。SGC2085 还选择性抑制 PRMT6，IC₅₀ 为 5.2 μM，但不抑制其他 PRMT 蛋白。

HY-163469

SRC-3-IN-2	Src	Cancer
SRC-3-IN-2 (SI-12 6c) 是一种具有口服活性的类固醇受体共激活因子 3 (SRC-3) 抑制剂。SRC-3-IN-2 具有抗肿瘤活性。

HY-100565A

SGC2085 hydrochloride	Histone Methyltransferase	Cancer
SGC2085 hydrochloride 是一种有效的选择性共激活剂相关精氨酸甲基转移酶 1 (CARM1) 抑制剂，IC₅₀ 为 50 nM。SGC2085 hydrochloride 还选择性抑制 PRMT6，IC₅₀ 为 5.2 μM，但不抑制其他 PRMT 蛋白。

HY-12407

ZK168281 1 篇文献验证	VD/VDR	Metabolic Disease
ZK168281 是一种 1α,25(OH)₂D₃ 类似物，也是一种纯 VDR 拮抗剂，K_d 值为 0.1 nM。ZK168281 是其受体 CoA 相互作用的有效抑制剂。

HY-W012248

KG-655	Aryl Hydrocarbon Receptor	Others
KG-655 是一种小分子化合物，能够与 ARNT PAS-B 的 β-折叠表面及其内部空腔结合，并干扰其与转录共激活因子 TACC3 的结合作用。KG-655 能促进 ARNT PAS-B 的同源二聚化，有潜力调节多条 ARNT 介导信号通路。

HY-152093

YL-939	Ferroptosis	Cancer
YL-939 是一种有效的铁死亡 (ferroptosis) 抑制剂。 YL-939 通过靶向 PHB2/铁蛋白/铁轴来抑制铁死亡。

HY-100855

DC_C66	Histone Methyltransferase	Cancer
DC_C66 是一种细胞渗透性的，选择性的 (CARM1) 抑制剂，IC₅₀ 值为 1.8 μM。DC_C66 相对 PRMT1 (IC₅₀=21 μM)，PRMT6 (IC₅₀= 47μM)，PRMT5，具有良好的选择性。

HY-19625A

(E/Z)-MCB-613	Reactive Oxygen Species (ROS) Paraptosis	Cancer
(E/Z)-MCB-613 是一种泛类固醇受体辅激活剂 (SRC) 刺激剂。(E/Z)-MCB-613 刺激癌细胞中的 SRC 活性，导致活性氧 (ROS) 过度生成，从而导致细胞应激和细胞副凋亡 (paraptosis)。(E/Z)-MCB-613 是一种细胞毒性分子，在癌症中发挥重要作用。

HY-P10843

R4K1	Estrogen Receptor/ERR	Cancer
R4K1 是一种细胞可渗透的钉合肽。R4K1 能够高亲和力结合雌激素受体 (ER) α ，并抑制其与共激活因子的相互作用。R4K1 可进入乳腺癌细胞中调控基因转录和抑制细胞增殖。R4K1 可用于肿瘤的研究。

HY-163468

SRC-3-IN-1	Src	Cancer
SRC-3- in -1 (compound SI-10) 是一种类固醇受体共激活因子 3 (SRC-3) 抑制剂 (IC₅₀=3.3 μM)。SRC-3-IN-1 具有良好的水溶性、口服生物利用度和选择性。SRC-3-IN-1 可用于前列腺癌研究。

HY-130479

AdipoR agonist 1	Adiponectin Receptor PPAR PGC-1α Sirtuin AMPK	Metabolic Disease
AdipoR agonist 1 (Compound 112254) 是脂联素受体 (AdipoR) 的激动剂，可激活转录调节因子，如过氧化物酶体增殖激活受体 (PPAR)、过氧化物酶体增殖激活受体γ 辅激活因子 1α (PGC-1α)、sirtuin 1 (SIRT1) 和腺苷酸活化蛋白激酶 (AMPK)。AdipoR agonist 1 可用于预防性刺激剂研究。

HY-43515

ESI1	Endogenous Metabolite	Metabolic Disease
ESI1 是一种小分子表观遗传沉默抑制剂。ESI1 可以触发主要脂质代谢调节因子 SREBP1/2 的核凝聚物形成，集中转录共激活因子以驱动脂质/胆固醇生物合成。ESI1 可以在脱髓鞘动物模型中促进髓鞘再生，并在再生的 CNS 轴突上实现从头髓鞘发生，逆转与年龄相关的认知能力下降。

HY-175264

MI891	Pregnane X Receptor (PXR) Cytochrome P450	Metabolic Disease
MI891 是一种高选择性的 PXR 拮抗剂 (IC₅₀ = 3.76 μM, K_d = 1.7 μM) 及反向激动剂 (IC₅₀ = 6.1 μM)。MI891 选择性破坏 PXR 与其共激活剂 SRC1 之间相互作用。MI891 有效抑制 Rifampicin (HY-B0272) 诱导的 PXR 激活。MI891 可用于代谢性等疾病的研究。

HY-15606

Tanaproget 1 篇文献验证 NSP-989	Progesterone Receptor	Endocrinology
Tanaproget 是一种口服有效、选择性的非甾体类孕激素受体 (PR) 激动剂，靶向人源 PR 的 IC₅₀=1.7 nM。Tanaproget 促进 PR 受体与共激活因子 (如 SRC-1) 的相互作用，从而抑制基质金属蛋白酶 (MMP-3/MMP-7) 的分泌，减少子宫内膜组织侵袭和血管生成。Tanaproget 可用于避孕、抑制子宫内膜异位症的研究。

HY-117182

LG190178	Apoptosis VD/VDR RAR/RXR	Metabolic Disease Inflammation/Immunology Cancer
LG190178 是一种非甾体维生素 D 受体 (VDR) 配体，能够诱导 VDR 与视黄酸 X 受体 (RXR) 形成异二聚体复合物，并稳定 VDR 配体结合域的激动构象，从而促进 VDR 与辅激活蛋白的相互作用。LG190178 具有调节钙稳态、骨矿化以及细胞增殖、分化和凋亡 (apoptosis) 的功能，因而可用于银屑病、骨质疏松症和癌症的研究。

HY-127024

Thyroid hormone receptor antagonist (1-850)	Thyroid Hormone Receptor	Metabolic Disease
Thyroid hormone receptor antagonist (1-850) 是一种竞争性、选择性、高亲和力的甲状腺激素受体 (TR) 拮抗剂，拮抗 T3 对 TR 的影响的 IC₅₀ 为 1.5 μM。Thyroid hormone receptor antagonist (1-850) 可阻断 T3 介导的 TRα 和 TRβ 与核受体共激活剂的相互作用。Thyroid hormone receptor antagonist (1-850) 对 RARα 的活性没有影响。

HY-127024A

TR antagonist 2	Thyroid Hormone Receptor	Metabolic Disease
TR antagonist 2 (Compound 10a) 是一种甲状腺激素受体 (TRα/β) 竞争性拮抗剂 (IC₅₀=47 nM)。TR antagonist 2 通过与三碘甲状腺原氨酸 (T₃) 竞争性结合 TR 的配体结合域，阻断受体-共激活因子复合物形成，抑制靶基因转录，降低甲状腺激素介导的代谢亢进效应。TR antagonist 2 有望用于甲状腺功能亢进 (如 Graves 病) 和甲状腺毒症的研究。

HY-173631

(S)-dHTC1	PROTACs	Cancer
(S)-dHTC1 是一种靶向转录共激活因子 ENL 的分子胶降解剂。 (S)-dHTC1 仅在形成 ENL:dHTC1 复合物后才能以高亲和力与连接酶结合，其 IC₅₀ 值为 93 nM。(S)-dHTC1 在 MV4; 11 细胞中降解 ENL 的 DC₅₀ 值为 26 nM。(S)-dHTC1 可用于急性髓系白血病研究。

HY-131445A

SS-RJW100	Orphan Receptor	Metabolic Disease Inflammation/Immunology
SS-RJW100 是 RJW100 的对映体，是核受体肝受体同源物 1 (LRH-1) 和类固醇生成因子 1 (SF-1) 的消旋激动剂。SS-RJW100 在体外促进共调节蛋白片段的招募，将转录中介因子 2 (Tif2) 共激活因子招募到 LRH-1。SS-RJW100 降低了LRH-1变构激活网络，表现出较差的热稳定性。

HY-116028

15-deoxy-Δ12,14-Prostaglandin D2 15-Deoxy-Δ12,14-PGD2	Endogenous Metabolite Prostaglandin Receptor PPAR Src	Cardiovascular Disease
15-deoxy-Δ12,14-Prostaglandin D2 (15-Deoxy-Δ12,14-PGD2) 是 PGD2 (HY-101988) 的代谢物，是 PGD2 受体 2 (DP2) 的激动剂。15-deoxy-Δ12,14-Prostaglandin D2 可结合 DP2（Ki=50 nM）并诱导嗜酸性粒细胞活化（EC₅₀=8 nM）。15-deoxy-Δ12,14-Prostaglandin D2 还刺激类固醇受体辅激活因子-1 (SRC-1) 向过氧化物酶体增殖激活受体 γ (PPARγ) 的募集，诱导 PPARγ 介导的转录。15-deoxy-Δ12,14-Prostaglandin D2 (15-Deoxy-Δ12,14-PGD2) 对 L1210 鼠白血病细胞具有细胞毒性（IC₅₀=0.3 μg/ml），并能够抑制 ADP 诱导的血小板聚集（IC₅₀=320 ng/mL）。

HY-14863

Lunacalcipol CTA-018	VD/VDR Cytochrome P450	Others Endocrinology
Lunacalcipol (CTA-018) 作为维生素 D 的类似物，在慢性肾病 (Chronic Kidney Disease, CKD) 的发病机制中具有双重作用，作为维生素 D 受体 (Vitamin D Receptor, VDR) 的激动剂和细胞色素 P450 酶24-羟化酶 (Cytochrome P450 enzyme 24-hydroxylase, CYP24A1) 的拮抗剂。Lunacalcipol 与 VDR 结合，通过影响配体结合亲和力、配体依赖的共激活因子招募或抑制因子解离、配体进入靶细胞的效率、组织特异性和配体的不同代谢等，调节 VDR 的转录活性。Lunacalcipol 可用于 CKD 的研究，特别是继发性甲状旁腺功能亢进 (Secondary Hyperparathyroidism, sHPT)。

HY-156152A

CARM1 degrader-1 hydrochloride	Histone Methyltransferase PROTACs	Cancer
CARM1 degrader-1 hydrochloride 是 CARM1 degrader-1 (HY-156152) 的盐酸盐形式。CARM1 degrader-1 hydrochloride 是辅激活剂相关精氨酸甲基转移酶 1 (CARM1) 的 PROTAC 降解剂，VHL 和蛋白酶依赖地降解 CARM1，DC₅₀ 为 8.1 nM。CARM1 degrader-1 hydrochloride 可抑制 CARM1 底物 (如聚腺苷酸结合蛋白 PABP1 和 BGR1 相关因子 BAF155) 甲基化并抑制乳腺癌细胞迁移。

HY-W722556

5α-Androstan-3α-ol 3α,5α-Androstanol	GABA Receptor Constitutive Androstane Receptor	Metabolic Disease
5α-Androstan-3α-ol 是一种γ-氨基丁酸 (GABA) 受体激动剂。5α-Androstan-3α-ol 能够抑制孤儿核受体 CAR (组成型雄烷受体) 的转录活性。5α-Androstan-3α-ol 通过结合 CAR 并促进其与共激活蛋白解离，从而负调控 CAR 的活性。5α-Androstan-3α-ol 可用于研究核受体介导的激素代谢和药物解毒机制。

HY-159912

pan-TEAD-IN-1	YAP	Cancer
pan-TEAD-IN-1 (Compound 3) 是一种具有口服活性的 TEAD 泛抑制剂，通过靶向 TEAD 的棕榈酰化位点，干扰其与共激活因子 YAP/TAZ 的相互作用，从而抑制 Hippo 信号通路中癌基因（如 Ctgf 和 Cyr61）的转录上调。pan-TEAD-IN-1 展现了优异的活性，对 luciferase IC₅₀ 为 0.36 nM，对 H226 细胞 IC₅₀ 为 1.52 nM，并具有较好的药代动力学特性 (AUC_0–∞ = 228.7 μg/mL·min，T_1/2 = 183.9 min)。在 TEAD 依赖型癌症的异种移植小鼠模型中，pan-TEAD-IN-1 显著抑制肿瘤生长。pan-TEAD-IN-1 有望用于研究 TEAD 依赖型癌症。

HY-126969

C333H	PPAR	Metabolic Disease
C333H是一种选择性PPARγ调节剂，具有胰岛素敏化和降糖活性。C333H在糖尿病鼠模型中展现出与噻唑烷二酮（TZDs）类似的胰岛素敏化效果，而不会显著增加体重或脂肪组织重量。C333H在糖尿病db/db小鼠中提高了循环高分子量脂联素亚型的水平，降低了棕色脂肪组织中PPARγ 273位点的丝氨酸磷酸化，并选择性调节了脂肪组织中特定PPARγ靶基因的表达。C333H在体外表现出弱招募共激活子和弱解离共抑制子的活性。这些特性表明C333H可能是一种有潜力的二型糖尿病抑制剂。

HY-171591

SIK2-IN-4	Salt-inducible Kinase (SIK) Interleukin Related TNF Receptor	Infection
SIK2-IN-4 (Compound 4) 是一种高选择性 SIK1/2 抑制剂 (IC_50s 分别为 0.143 和 0.076 μM)。SIK2-IN-4 通过靶向 SIK1/2 减少转录辅激活因子3 (CRTC3) 的磷酸化，从而调节 cAMP 反应元件结合蛋白 (CREB) 依赖的转录活性。SIK2-IN-4 能够抑制促炎细胞因子 (如 TNF (IC₅₀: 0.11 µM)、IL-12/23 p40 (IC₅₀: 0.25 µM) 和 IL-23 (IC₅₀: 0.47 µM)) 的产生，同时诱导抗炎细胞因子 IL-10 的表达。SIK2-IN-4 能够用于肠道炎症和其他慢性炎症疾病的研究。

Cat. No.	Product Name	Target	Research Area

HY-P2515

Transcriptional Intermediary Factor 2 (TIF2) (740-753)	Histone Acetyltransferase	Others
Transcriptional Intermediary Factor 2 (TIF2) (740-753) 是转录中介因子 2 (TIF2) 的共激活肽，由 TIF-2 蛋白的 14 个氨基酸残基 (⁷⁴⁰KENALLRYLLDKDD⁷⁵³) 组成。

HY-P5458

SRC-1 (686-700)	Mineralocorticoid Receptor	Others
SRC-1 (686-700) 是一种有生物活性的肽。(该肽是氨基酸 686 至 700 的片段，包含第二个 LXXLL 基序，源自类固醇受体共激活剂 (SRC1) 的 NR 盒 II。共激活蛋白以配体依赖性方式与核受体相互作用并增强转录。)

HY-P10843

R4K1	Estrogen Receptor/ERR	Cancer
R4K1 是一种细胞可渗透的钉合肽。R4K1 能够高亲和力结合雌激素受体 (ER) α ，并抑制其与共激活因子的相互作用。R4K1 可进入乳腺癌细胞中调控基因转录和抑制细胞增殖。R4K1 可用于肿瘤的研究。

Species:	Human (5)
Tag:	His (5) SUMO (3)
Source:	E. coli (5)

Cat. No.	Compare	Product Name	Species	Source

HY-P74650

	PC4/SUB1 Protein, Human (His) Activated RNA polymerase II transcriptional coactivator p15; PC4; p14; SUB1; RPO2TC1	Human	E. coli
	PC4 蛋白/SUB1 蛋白 PC4/SUB1 蛋白充当多功能共激活剂，与 TAF 配合促进上游激活剂和一般转录机制之间的功能相互作用。它的作用延伸到多蛋白转录复合物的潜在稳定性。PC4/SUB1 Protein, Human (His) 是重组的 PC4/SUB1 蛋白，由 E. coli 表达，带有 N-His 标签。

HY-P790095

	CARM1 Protein, Human (His) Histone-arginine methyltransferase CARM1; coactivator-associated arginine methyltransferase 1; Protein arginine N-methyltransferase 4; CARM1; PRMT4	Human	E. coli
	CARM1 蛋白 CARM1 Protein, Human (His) 是重组的 CARM1 蛋白，由 E. coli 表达，带有 C-10*His 标签。

HY-P71612

	RBM14 Protein, Human (His-SUMO) RBM14; SIP; RNA-binding protein 14; Paraspeckle protein 2; PSP2; RNA-binding motif protein 14; RRM-containing coactivator activator/modulator; Synaptotagmin-interacting protein; SYT-interacting protein	Human	E. coli
	RBM14 蛋白 RBM14 蛋白具有具有多种功能的不同亚型。同工型 1 作为核受体共激活剂增强转录，与 NCOA6 和 CITED1 相互作用。RBM14 Protein, Human (His-SUMO) 是重组的 RBM14 蛋白，由 E. coli 表达，带有 N-SUMO, N-6*His 标签。

HY-P72201

	GAPDH Protein, Human (His-SUMO) G3P_HUMAN; G3PD; G3PDH; GAPD; GAPDH; Glyceraldehyde 3 phosphate dehydrogenase; glyceraldehyde 3-PDH; Glyceraldehyde-3-phosphate dehydrogenase; HEL-S-162eP; KNC-NDS6; MGC102544; OCAS; p38 component; OCT1 coactivator in S phase; 38-KD component; peptidyl cysteine S nitrosylase GAPDH	Human	E. coli
	GAPDH 蛋白 GAPDH 是一种多功能蛋白，作为糖酵解中的关键酶，催化 G3P 的转化。它还充当亚硝基酶，影响核过程。此外，它还影响细胞骨架组织，与 CHP1 相关，参与转录选择性翻译抑制，有助于免疫反应，并通过靶蛋白的 S-亚硝基化介导核事件。GAPDH Protein, Human (His-SUMO) 是重组的 GAPDH 蛋白，由 E. coli 表达，带有 N-6*His, N-SUMO 标签。

HY-P71608

	TGS1 Protein, Human (His-SUMO) Cap specific guanine N2 methyltransferase; Cap-specific guanine-N2 methyltransferase; CLL associated antigen KW 2; CLL-associated antigen KW-2; DKFZp762A163; FLJ22995; HCA137; Hepatocellular carcinoma associated antigen 137; Hepatocellular carcinoma-associated antigen 137; NCOA6IP; Nuclear receptor coactivator 6 interacting protein; Nuclear receptor coactivator 6-interacting protein; PIMT; PIPMT; PRIP interacting protein PIPMT; PRIP interacting protein with methyltransferase domain; PRIP interacting protein with methyltransferase motif; PRIP-interacting protein with methyltransferase motif; SEREX defined; TGS 1; Tgs1; TGS1_HUMAN; Trimethylguanosine synthase; Trimethylguanosine synthase homolog (S. cerevisiae); Trimethylguanosine synthase homolog	Human	E. coli
	TGS1 蛋白 TGS1 蛋白催化小核 RNA (snRNA) 和小核仁 RNA (snoRNA) 的 7-单甲基鸟苷 (m(7)G) 帽转化为 2, 2,7-三甲基鸟苷 (m( 2,2,7)G ) 帽结构。该酶对鸟嘌呤表现出特异性，在修饰过程中，N7 甲基化发生在 N2 甲基化之前。TGS1 Protein, Human (His-SUMO) 是重组的 TGS1 蛋白，由 E. coli 表达，带有 N-His, N-SUMO 标签。

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标签
蛋白编号
基因 ID
分子量
纯度
内毒素含量
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性状
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Cat. No.	Product Name	Chemical Structure

HY-17538S

ZLN005-d4
ZLN005-d₄ 是 ZLN005 氘代物。ZLN005 是新型过氧化物增殖激活受体协同激活子 (PGC-1α) 激活剂。

HY-101491S

SR-18292-d9
SR-18292-d₉ 是一种 SR-18292 (HY-101491) 的氘代物。SR-18292 是一种 PPARγ 共激活因子-1α (PGC-1α) 抑制剂，可促进 PGC-1α 乙酰化，抑制糖异生基因的表达，并减少肝细胞中葡萄糖的产生。

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P83728

	PGC1 alpha+beta Antibody (YA3458) LEM6 antibody; Ligand effect modulator 6 antibody; PERC antibody; Peroxisome proliferative activated receptor, gamma, coactivator 1 antibody; PGC 1 alpha antibody; PGC-1-beta antibody; PGC-1-related estrogen receptor alpha coactivator antibody; PGC1 antibody; PGC1A antibody; PGC1v antibody; PPAR gamma coactivator 1 alpha antibody; PPAR gamma coactivator-1 beta antibody; PPARGC 1 alpha antibody; PPARGC-1-beta antibody; PPARGC1 antibody; PPARGC1A antibody; Ppargc1b antibody; PRGC1_HUMAN antibody; PRGC2_HUMAN antibody;	WB	Human, Mouse, Rat
	PGC1 alpha+beta Antibody (YA3458) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3458), targeting PGC1 alpha+beta , with a predicted molecular weight of 91/113 kDa (observed band size:110 kDa). PGC1 alpha+beta Antibody (YA3458) can be used for WB experiment in human, mouse, rat background.

HY-P80783

	PGC1 alpha Antibody PPARGC1A; LEM6; PGC1; PGC1A; PPARGC1; Peroxisome proliferator-activated receptor gamma coactivator 1-alpha; PGC-1-alpha; PPAR-gamma coactivator 1-alpha; PPARGC-1-alpha; Ligand effect modulator 6	WB	Human, Mouse, Rat
	PGC1 alpha Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 91 kDa, targeting to PGC1 alpha. It can be used for WB assays with tag free, in the background of Human, Mouse, Rat.

HY-P85326

	PGC1 alpha Antibody (YA5018) PPARGC1A; LEM6; PGC1; PGC1A; PPARGC1; Peroxisome proliferator-activated receptor gamma coactivator 1-alpha; PGC-1-alpha; PPAR-gamma coactivator 1-alpha; PPARGC-1-alpha; Ligand effect modulator 6	WB, ELISA	Human
	PGC1 alpha Antibody (YA5018) is a mouse-derived and non-conjugated monoclonal antibody, targeting to PGC-1α. It can be applicated for WB, ELISA assays, in the background of human.

HY-P85400

	SND1/P100 Antibody (YA5092) SND1; TDRD11; Staphylococcal nuclease domain-containing protein 1; 100 kDa coactivator; EBNA2 coactivator p100; Tudor domain-containing protein 11; p100 co-activator	WB, ELISA	Human
	SND1/P100 Antibody (YA5092) is a mouse-derived and non-conjugated monoclonal antibody, targeting to TudorSN. It can be applicated for WB, ELISA assays, in the background of human.

HY-P85293

	NCoA-3 Antibody (YA4985) NCOA3; AIB1; BHLHE42; RAC3; TRAM1; Nuclear receptor coactivator 3; NCoA-3; ACTR; Amplified in breast cancer 1 protein; AIB-1; CBP-interacting protein; pCIP; Class E basic helix-loop-helix protein 42; bHLHe42; Receptor-associated coactivator	WB, ELISA	Human
	NCoA-3 Antibody (YA4985) is a mouse-derived and non-conjugated monoclonal antibody, targeting to NCoA-3. It can be applicated for WB, ELISA assays, in the background of human.

HY-P84934

	NCOA4 Antibody (YA4630) 70 kDa androgen receptor activator antibody; 70 kDa androgen receptor coactivator antibody; 70 kDa AR activator antibody; 70 kDa AR-activator antibody; Androgen receptor coactivator 70 kD antibody; Androgen receptor coactivator 70 kDa protein antibody; Androgen receptor-associated protein of 70 kDa antibody; ARA 70 antibody; ARA70 antibody; DKFZp762E1112 antibody; ELE 1 antibody; ELE1 antibody; ELE1/ret TK antibody; NCOA 4 antibody; NCoA-4 antibody; NCOA4 antibody; NCOA4_HUMAN antibody; Nuclear receptor coactivator 4 antibody; Papillary thyroid carcinoma 3 antibody; PTC 3 antibody; PTC3 antibody; RET activating gene ELE1 antibody; Ret activating protein ELE1 antibody; Ret-activating protein ELE1 antibody; RFG antibody	WB	Human
	NCOA4 Antibody (YA4630) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA4630), targeting NCOA4. NCOA4 Antibody (YA4629) can be used for WB experiment in human background.

HY-P84935

	NCOA4 Antibody (YA4631) 70 kDa androgen receptor activator antibody; 70 kDa androgen receptor coactivator antibody; 70 kDa AR activator antibody; 70 kDa AR-activator antibody; Androgen receptor coactivator 70 kD antibody; Androgen receptor coactivator 70 kDa protein antibody; Androgen receptor-associated protein of 70 kDa antibody; ARA 70 antibody; ARA70 antibody; DKFZp762E1112 antibody; ELE 1 antibody; ELE1 antibody; ELE1/ret TK antibody; NCOA 4 antibody; NCoA-4 antibody; NCOA4 antibody; NCOA4_HUMAN antibody; Nuclear receptor coactivator 4 antibody; Papillary thyroid carcinoma 3 antibody; PTC 3 antibody; PTC3 antibody; RET activating gene ELE1 antibody; Ret activating protein ELE1 antibody; Ret-activating protein ELE1 antibody; RFG antibody	IHC-P, IF-Tissue	Human, Mouse, Rat
	NCOA4 Antibody (YA4631) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA4631), targeting NCOA4. NCOA4 Antibody (YA4631) can be used for IHC-P, IF-Tissue experiment in Human, Mouse, Rat background.

HY-P85393

	TORC2 Antibody (YA5085) CRTC2; TORC2; CREB-regulated transcription coactivator 2; Transducer of regulated cAMP response element-binding protein 2; TORC-2; Transducer of CREB protein 2	WB, IHC-P, ICC/IF, FC, ELISA	Human, Monkey
	TORC2 Antibody (YA5085) is a mouse-derived and non-conjugated monoclonal antibody, targeting to TORC2. It can be applicated for WB, IHC-P, ICC/IF, FC, ELISA assays, in the background of human, monkey.

HY-P85394

	TORC3 Antibody (YA5086) CRTC3; TORC3; CREB-regulated transcription coactivator 3; Transducer of regulated cAMP response element-binding protein 3; TORC-3; Transducer of CREB protein 3	WB, IHC-P, ICC/IF, ELISA	Human, Monkey
	TORC3 Antibody (YA5086) is a mouse-derived and non-conjugated monoclonal antibody, targeting to TORC3. It can be applicated for WB, IHC-P, ICC/IF, ELISA assays, in the background of human, monkey.

HY-P85478

	TORC1 Antibody (YA5170) CRTC1; KIAA0616; MECT1; TORC1; WAMTP1; CREB-regulated transcription coactivator 1; Mucoepidermoid carcinoma translocated protein 1; Transducer of regulated cAMP response element-binding protein 1; TORC-1; Transducer of CREB protein 1	WB, FC, ICC/IF	Human, Mouse, Rat, Pig
	TORC1 Antibody (YA5170) is a mouse-derived and non-conjugated monoclonal antibody, targeting to TORC1. It can be applicated for WB, FC, ICC/IF assays, in the background of human, mouse, rat, pig.

HY-P87110

	TMF Antibody (YA6803) Androgen receptor coactivator 160 kDa protein antibody; Androgen receptor-associated protein of 160 kDa antibody; ARA160 antibody; TATA element modulatory factor 1 antibody; TATA element modulatory factor antibody; TMF antibody; Tmf1 antibody; TMF1_HUMAN antibody	WB, ICC/IF, IHC-P	Human

HY-P85445

	NSD1 Antibody (YA5137) NSD1; ARA267; KMT3B; Histone-lysine N-methyltransferase; H3 lysine-36 and H4 lysine-20 specific; Androgen receptor coactivator 267 kDa protein; Androgen receptor-associated protein of 267 kDa; H3-K36-HMTase; H4-K20-HMTase; Lysine N-methyltr	WB	Human
	NSD1 Antibody (YA5137) is a mouse-derived and non-conjugated monoclonal antibody, targeting to NSD1. It can be applicated for WB assays, in the background of human.

HY-P85492

	CARM1 Antibody (YA5184) carm1; CARM1_HUMAN; coactivator associated arginine methyltransferase 1; coactivator-associated arginine methyltransferase 1; Histone arginine methyltransferase CARM 1; Histone arginine methyltransferase CARM1; Histone-arginine methyltransferase CARM1; PRMT 4; PRMT4; Protein arginine methyltransferase; Protein arginine N methyltransferase 4; Protein arginine N-methyltransferase 4.	WB, IP	Human, Mouse
	CARM1 Antibody (YA5184) is a mouse-derived and non-conjugated monoclonal antibody, targeting to CARM1. It can be applicated for WB, IP assays, in the background of human, mouse.

HY-P85335

	CARM1 Antibody (YA5027) CARM1; PRMT4; Histone-arginine methyltransferase CARM1; coactivator-associated arginine methyltransferase 1; Protein arginine N-methyltransferase 4	WB, IHC-P, ICC/IF, FC, ELISA	Human, Rat, Monkey
	CARM1 Antibody (YA5027) is a mouse-derived and non-conjugated monoclonal antibody, targeting to CARM1. It can be applicated for WB, IHC-P, ICC/IF, FC, ELISA assays, in the background of human, rat, monkey.

HY-P85829

	BOB1 Antibody (YA5521) B cell Oct binding protein 1; B cell specific coactivator OBF 1; B cell specific coactivator OBF1; B-cell-specific coactivator OBF-1; BOB 1; BOB-1; OBF 1; OBF1; OBF1_HUMAN; OCA B; OCA-B; OCAB; OCT binding factor 1; OCT-binding factor 1; POU class 2 associating factor 1; POU domain class 2 associating factor 1; POU domain class 2-associating factor 1; Pou2af1	IHC-P, WB, ICC/IF, ELISA	Human, Mouse,
	BOB1 Antibody (YA5521) is a mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to BOB.1. It can be applicated for IHC-P, WB, ICC/IF, ELISA assays, in the background of human, mouse.

HY-P82334

	Aly Antibody (YA2079) ALYREF; ALY; BEF; THOC4; THO complex subunit 4; Tho4; Ally of AML-1 and LEF-1; Aly/REF export factor; Transcriptional coactivator Aly/REF; bZIP-enhancing factor BEF	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	Aly Antibody (YA2079) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2079), targeting Aly, with a predicted molecular weight of 27 kDa (observed band size: 27 kDa). Aly Antibody (YA2079) can be used for WB, IHC-F, IHC-P, ICC/IF, IP experiment in human, mouse, rat background.

HY-P85256

	PSIP1/LEDGF Antibody (YA4948) PSIP1; DFS70; LEDGF; PSIP2; PC4 and SFRS1-interacting protein; CLL-associated antigen KW-7; Dense fine speckles 70 kDa protein; DFS 70; Lens epithelium-derived growth factor; Transcriptional coactivator p75/p52	WB, IHC-P, ICC/IF, ELISA	Human, Rat, Monkey
	PSIP1/LEDGF Antibody (YA4948) is a mouse-derived and non-conjugated monoclonal antibody, targeting to LEDGF. It can be applicated for WB, IHC-P, ICC/IF, ELISA assays, in the background of human, rat, monkey.

HY-P86849

	Dcp1a Antibody (YA6542) DCP1 decapping enzyme homolog A antibody; Dcp1a antibody; DCP1A_HUMAN antibody; Decapping enzyme hDcp1a antibody; Decapping mRNA 1A antibody; HSA275986 antibody; mRNA decapping enzyme 1A antibody; mRNA-decapping enzyme 1A antibody; Nbla00360 antibody; Putative protein product of Nbla00360 antibody; DCP1 decapping enzyme homolog A antibody; Dcp1a antibody; DCP1A_HUMAN antibody; Decapping enzyme hDcp1a antibody; Decapping mRNA 1A antibody; HSA275986 antibody; mRNA decapping enzyme 1A antibody; mRNA-decapping enzyme 1A antibody; Nbla00360 antibody; Putative protein product of Nbla00360 antibody; Smad4 interacting transcriptional co activator antibody; Smad4-interacting transcriptional co-activator antibody; Smad4-interacting transcriptional co-activator antibody; SMAD4IP1 antibody; SMIF antibody; Transcription factor SMIF antibody	WB, IHC-P	Human, Mouse, Rat

HY-P87083

	SP110 Antibody (YA6776) FLJ22835 antibody; IFI 41 antibody; IFI 75 antibody; IFI41 antibody; IFI75 antibody; Interferon induced protein 41 30kD antibody; Interferon induced protein 41 antibody; Interferon induced protein 41/75 antibody; Interferon induced protein 75 52kD antibody; Interferon induced protein 75 antibody; FLJ22835 antibody; IFI 41 antibody; IFI 75 antibody; IFI41 antibody; IFI75 antibody; Interferon induced protein 41 30kD antibody; Interferon induced protein 41 antibody; Interferon induced protein 41/75 antibody; Interferon induced protein 75 52kD antibody; Interferon induced protein 75 antibody; Interferon-induced protein 41/75 antibody; IPR 1 antibody; IPR1 antibody; Phosphoprotein 41 antibody; Phosphoprotein 75 antibody; SP 110 antibody; SP110 antibody; Sp110 nuclear body protein antibody; SP110_HUMAN antibody; Speckled 110 kDa antibody; Transcriptional coactivator Sp110 antibody; VODI antibody	WB, IHC-P, IF-Tissue	Human, Mouse, Rat

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