2. Protein Tyrosine Kinase/RTK Apoptosis
  3. Src Apoptosis
  4. SI-2

SI-2 (EPH 116) 是类固醇受体辅激活剂 3 (SRC-3) 的抑制剂，可降低细胞中 SRC-3 的转录活性和蛋白质水平，对癌细胞具有细胞毒性，可抑制 MDA-MB-468 的迁移，诱导 MDA-MB-468 细胞凋亡 (apoptosis)。SI-2 可抑制小鼠模型中的肿瘤生长，且对心脏和其他主要器官无明显毒性（20 mg/kg）。

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SI-2

SI-2 Chemical Structure

CAS No. : 223788-33-8

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SI-2 的其他形式现货产品:

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SI-2 相关抗体

Top Publications Citing Use of Products

查看 Src 亚型特异性产品:

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Lck Fyn Blk Fgr Hck Lyn Yes SRC-3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SI-2 (EPH 116) is an inhibitor for steroid receptor coactivator-3 (SRC-3), which reduces the transcriptional activity and protein concentration of SRC-3 in cells, exhibits cytotoxicity in cancer cell, inhibits migration of MDA-MB-468, induces apoptosis of MDA-MB-468. SI-2 inhibits the tumor growth in mouse models, without significant toxicity for heart and other major organs (20 mg/kg)[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
MCF7 IC50
22 nM
Compound: SI-2
Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 38551814]
TOV112D EC50
0.004 μM
Compound: C9
Growth inhibition of human TOV112D cells harbouring p53 R175H mutant incubated for 3 days by MTS assay
Growth inhibition of human TOV112D cells harbouring p53 R175H mutant incubated for 3 days by MTS assay
[PMID: 33538587]
分子量

265.31

Formula

C15H15N5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SI-2 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SI-2223788-33-8EPH 116SI2SI 2EPH116EPH-116SrcApoptosisMDA-MB-468MCF-7T47DBT-474HeLaHEK293CD-1 mouseInhibitorinhibitorinhibit

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