2. Metabolic Enzyme/Protease
  3. Epoxide Hydrolase
  4. sEH inhibitor-12

sEH inhibitor-12 (compound 34) 是 sEH 的抑制剂，IC50 值为 0.7 μM。sEH inhibitor-12 抑制 5-脂氧合酶激活蛋白 (FLAP) 介导的白三烯 (LT) 合成，IC50 值为 2.9 μM。sEH inhibitor-12 可用于炎症的研究。

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sEH inhibitor-12 Chemical Structure

sEH inhibitor-12 Chemical Structure

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sEH inhibitor-12 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

sEH inhibitor-12 (compound 34) is a sEH inhibitor with an IC50 value of 0.7 μM. sEH inhibitor-12 inhibits the 5-lipoxygenase-activating protein (FLAP)-mediated leukotriene (LT) biosynthesis with an IC50 value of 2.9 μM. sEH inhibitor-12 can be used for the research of inflammation[1].

IC50 & Target

IC50: 0.7 μM (sEH), 2.9 μM (FLAP-mediated LT biosynthesis)[1]
体外研究
(In Vitro)

sEH inhibitor-12 (0-10 μM; 10 min) inhibits sEH activity with an IC50 value of 0.7 μM[1].
sEH inhibitor-12 (0-10 μM) inhibits FLAP-mediated cellular LT formation with an IC50 value of 2.9 μM[1].
sEH inhibitor-12 (15 min) remains the activity of 5-lipoxygenase (5-LO) product formation in neutrophils with 84.5% and 4.5% at doses of 1 and 10 μM, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

sEH inhibitor-12 相关抗体:
分子量

415.94

Formula

C21H22ClN3O2S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

sEH inhibitor-12 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

sEH inhibitor-12sEH inhibitor12sEH inhibitor 12Epoxide Hydrolasequinazolinone-7-carboxylic acidderivativeFLAP5-LOLTneutrophilsleukotrieneInhibitorinhibitorinhibit

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