1. Metabolic Enzyme/Protease
  2. Lipoxygenase
  3. Setileuton

Setileuton  (Synonyms: MK-0633)

目录号: HY-10437
产品使用指南

Setileuton (MK-0633) 是 5-脂氧合酶 (5-lipoxygenase) 的抑制剂,可以抑制人重组 5-脂氧合酶中花生四烯酸的氧化,以及人类全血中钙离子载体刺激的 LTB4 的产生,IC50 分别为 3.9 和 52 nM。

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Setileuton Chemical Structure

Setileuton Chemical Structure

CAS No. : 910656-27-8

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Customer Review

查看 Lipoxygenase 亚型特异性产品:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Setileuton (MK-0633) is an inhibitor for 5-lipoxygenase, that inhibits the oxidation of arachidonic acid by recombinant human 5-LO, and the production of LTB4 in calcium ionophore-stimulated human whole blood, with IC50 of 3.9 and 52 nM, respectively[1].

体内研究
(In Vivo)

Setileuton (5 mg/kg,静脉注射;20 mg/kg,口服,单剂量) 在大鼠模型中表现出良好的药代动力学特征,半衰期 T1/2 为 3.3 小时,生物利用度为 66%[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

463.38

Formula

C22H17F4N3O4

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

Setileuton 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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目录号:
HY-10437
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