1. Cell Cycle/DNA Damage Epigenetics
  2. Sirtuin
  3. SIRT2-IN-11

SIRT2-IN-11 (AEM1) 是选择性的 SIRT2 抑制剂,IC50 值为 18.5 μM。SIRT2-IN-11 以 p53 依赖的诱导细胞凋亡,激活 CDKN1APUMANOXA 的表达,并且促进 p53 的乙酰化。SIRT2-IN-11 可用于 p53 相关的癌症研究。

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SIRT2-IN-11 Chemical Structure

SIRT2-IN-11 Chemical Structure

CAS No. : 1005095-06-6

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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SIRT2-IN-11 (AEM1) is a selective SIRT2 inhibitor with an IC50 value of 18.5 μM. SIRT2-IN-11 p53-dependently induces apoptosis, activates expression of CDKN1A, PUMA and NOXA, and increases acetylation of p53. SIRT2-IN-11 can be used for the research of p53-related cancers[1].

IC50 & Target

SIRT2

18.5 μM (IC50)

SIRT1

118.4 μM (IC50)

体外研究
(In Vitro)

SIRT2-IN-11 (0-1000 μM) shows inhibitory effect of SIRT2-dependent deacetylation of MAL with an IC50 value of 18.5 μM[1].
SIRT2-IN-11 (0-1000 μM) weakly inhibits SIRT1 with an IC50 value of 118.4 μM[1].
SIRT2-IN-11 (0-20 μM; 8 h) induces cell apoptosis of lung cancer cells[1].
SIRT2-IN-11 (20 μM; 6 h) increases p53 acetylation and expression levels of Cp53 target genes CDKN1A, PUMA and NOXA[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR[1]

Cell Line: NSCLC cell lines
Concentration: 20 μM
Incubation Time: 6 hours
Result: Increased the expression of CDKN1A, PUMA and NOXA.

Apoptosis Analysis[1]

Cell Line: A549 cell line
Concentration: 0, 0.5, 1, 5, 10 and 20 μM
Incubation Time: 24 hours
Result: Mildly increased apoptosis of A549 cells, but when combined treatment with etoposide caused a marked increase in apoptosis.
分子量

318.41

Formula

C21H22N2O

CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : 250 mg/mL (785.15 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.1406 mL 15.7030 mL 31.4060 mL
5 mM 0.6281 mL 3.1406 mL 6.2812 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

SIRT2-IN-11 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1406 mL 15.7030 mL 31.4060 mL 78.5151 mL
5 mM 0.6281 mL 3.1406 mL 6.2812 mL 15.7030 mL
10 mM 0.3141 mL 1.5703 mL 3.1406 mL 7.8515 mL
15 mM 0.2094 mL 1.0469 mL 2.0937 mL 5.2343 mL
20 mM 0.1570 mL 0.7852 mL 1.5703 mL 3.9258 mL
25 mM 0.1256 mL 0.6281 mL 1.2562 mL 3.1406 mL
30 mM 0.1047 mL 0.5234 mL 1.0469 mL 2.6172 mL
40 mM 0.0785 mL 0.3926 mL 0.7852 mL 1.9629 mL
50 mM 0.0628 mL 0.3141 mL 0.6281 mL 1.5703 mL
60 mM 0.0523 mL 0.2617 mL 0.5234 mL 1.3086 mL
80 mM 0.0393 mL 0.1963 mL 0.3926 mL 0.9814 mL
100 mM 0.0314 mL 0.1570 mL 0.3141 mL 0.7852 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
SIRT2-IN-11
目录号:
HY-148408
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