2. Apoptosis
  3. MDM-2/p53
  4. SPDI-48-T1

SPDI-48-T1 是一种赖氨酸交联肽。SPDI-48-T1 对 MDM2 和 MDMX 具有明显的结合亲和力，其 Kd 值分别为 396 nM 和 456 nM。SPDI-48-T1 对乳腺癌、结直肠癌、非小细胞肺癌、宫颈癌和恶性黑色素瘤均具有抗癌活性。

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Custom Peptide Synthesis

SPDI-48-T1

SPDI-48-T1 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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Customer Review

SPDI-48-T1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SPDI-48-T1 is a lysine-stapled peptide. SPDI-48-T1 exhibits discernible binding affinities for MDM2 and MDMX, with Kd values of 396 nM and 456 nM, respectively. SPDI-48-T1 exhibits anticancer activity against breast cancer, colorectal cancer, non-small cell lung cancer, cervical cancer, and malignant melanoma[1].

IC50 & Target

Kd: 396 nM (MDM2) and 456 nM (MDMX)[1]
分子量

1837.13

Formula

C91H129N21O20
Sequence

Ac-Leu-Thr-Phe-Lys-His-Tyr-Trp-Lys-Gln-Leu-Thr-Ser-Ala-Ala-NH2 (Lys stapled via 1,3-bismethylenebenzene)
Sequence Shortening

Ac-LTFKHYWKQLTSAA-NH2 (Lys stapled via 1,3-bismethylenebenzene)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SPDI-48-T1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SPDI-48-T1MDM-2/p53AntitumorHCT116nude mouseZR-75-1A549HeLaA375Inhibitorinhibitorinhibit

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产品名称：
SPDI-48-T1
目录号：
HY-P11255
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