2. Immunology/Inflammation
  3. STING Interleukin Related
  4. STING-IN-13

STING-IN-13 是一种选择性 STING 抑制剂。 STING-IN-13 能有效抑制 STING 通路的下游信号传导，抑制 STING 介导的炎症。STING-IN-13 毒性较低，可用于 STING 相关炎症和自身免疫性疾病的研究。

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STING-IN-13

STING-IN-13 Chemical Structure

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Customer Review

STING-IN-13 相关抗体

Top Publications Citing Use of Products

查看 Interleukin Related 亚型特异性产品:

查看所有亚型
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

STING-IN-13 is a selective STING inhibitor. STING-IN-13 can effectively inhibit downstream signaling of the STING pathway and inhibit STING-mediated inflammation. STING-IN-13 has low toxicity and can be used to study STING-related inflammatory and autoimmune diseases[1].

体外研究
(In Vitro)

STING-IN-13 (Compound HY2) (30 μM) 在 RAW264.7 细胞中显示出与 STING 的直接相互作用[1]。
STING-IN-13 (0.03 μM-0.3 μM, 预处理 1 小时，然后共孵育 2-4 小时) 有效抑制了 SR717 (HY-131454) 诱导的 THP1 和 RAW264.7 细胞中 STING 通路的下游信号传导，有效减少炎症因子 IFN-β 和 CXCL10 的产生[1]。
STING-IN-13 (0.4 μM-3.3 μM, 48 h) 在 THP1 细胞中有着优异的安全性，细胞毒性低[1]。
STING-IN-13 (5 μM, 预处理 1 小时，然后再处理 2 小时) 在 THP1 细胞中只特异性抑制 STING 驱动的 IFNβ 表达，而不会影响 TLR 通路[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

STING-IN-13 相关抗体:

Real Time qPCR[1]

Cell Line: SR717 (30 μM) treated THP1 and RAW264.7 cells
Concentration: 0.03 μM-0.3 μM
Incubation Time: Pretreatment for 1 h, then SR717 treatment for 4 h
Result: Dose-dependently reduced IFN-β and CXCL10 levels induced by SR717 in THP1 and RAW264.7 cells.
体内研究
(In Vivo)

STING-IN-13 (Compound HY2) (10,20 mg/kg, i.p. one dose) 在顺铂 (HY-17394) 诱导的 AKI 小鼠模型中，具有提高生存率，保护肾功能和肝功能的作用，减轻肾小管损伤和炎症细胞浸润[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 mice (male, aged 8 weeks) injected with Cisplatin (25 mg/kg)[1]
Dosage: 10,20 mg/kg
Administration: i.p. one dose
Result: Effectively improved the survival rate (100% vs 33.3% in the Cisplatin group).
Reduced BUN and creatinine levels, protected renal function, and reduced AST and ALT levels, protecting the liver.
Reduced renal tubular damage and inflammatory cell infiltration.
分子量

377.36

Formula

C19H18F3N3O2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

STING-IN-13 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

STING-IN-13STINGInterleukin RelatedStimulator of Interferon GenesTMEM173MITAERISMPYSILInflammationTHP1 cellsRAW264.7 cellskidney damageAKI mouse modelInhibitorinhibitorinhibit

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产品名称：
STING-IN-13
目录号：
HY-173317
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