2. Anti-infection
  3. Antibiotic Bacterial
  4. Sulfathiazole

Sulfathiazole  (Synonyms: 磺胺噻唑)

目录号: HY-B0507 纯度: 99.71%
COA 产品使用指南 技术支持

Sulfathiazole 是一种口服有效、靶向类固醇生成途径的内分泌干扰剂，尤其能增强人肾上腺癌细胞 (H295R) 中 CYP19 的活性，并上调 CYP17、CYP19 和 3β-HSD 的 mRN 表达。Sulfathiazole 增加 17-雌二醇 (E2) 的产生，对水生生物 (如日本青鳉鱼) 的内分泌具有干扰效应。Sulfathiazole 也是一种阴极型缓蚀剂，通过在铜表面发生化学吸附和物理吸附，抑制氯离子对铜的侵蚀，降低腐蚀电流密度并使腐蚀电位负移。

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Sulfathiazole

Sulfathiazole Chemical Structure

CAS No. : 72-14-0

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥220
In-stock
500 mg ￥200
In-stock
1 g ￥300
In-stock
5 g ￥600
In-stock
10 g ￥867
In-stock
50 g   询价  

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Customer Review

Other Forms of Sulfathiazole:

Sulfathiazole 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Sulfathiazole is an orally active, endocrine disruptor targeting the steroidogenic pathway, specifically enhancing the activity of CYP19 in human adrenal cancer cells (H295R) and upregulating the mRN expression of CYP17, CYP19, and 3β-HSD. Sulfathiazole increases the production of 17-estradiol (E2) and has endocrine disrupting effects on aquatic organisms such as the Japanese medaka fish[1][2][3].

IC50 & Target

Antibacterial
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HepG2 IC50
4161 μM
Compound: 3a
Cytotoxicity against human HepG2 cells after 24 hrs by MTS assay
Cytotoxicity against human HepG2 cells after 24 hrs by MTS assay
[PMID: 22365879]
Sf9 IC50
430 μM
Compound: 19
Inhibition of N-terminal hexa-His tagged human PRMT6 expressed in Sf9 cells using 24 residues of biotin labelled histone4 substrate and tritiated 3H-S-adenosylmethionine by scintillation proximity assay
Inhibition of N-terminal hexa-His tagged human PRMT6 expressed in Sf9 cells using 24 residues of biotin labelled histone4 substrate and tritiated 3H-S-adenosylmethionine by scintillation proximity assay
[PMID: 26824386]
体外研究
(In Vitro)

Sulfathiazole (0.02-20 mg/L；48 h) 在人肾上腺癌细胞 (H295R) 实验中可显著增加 17-雌二醇 (E2) 生成、芳香化酶 (CYP19) 活性及 CYP17、CYP19、3βHSD 等类固醇生成相关基因的 mRNA 表达[1]。
Sulfathiazole 能有效抑制铜在 0.1 M NaCl 溶液中的腐蚀，抑制效率随浓度升高可达 80% 以上[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Sulfathiazole 相关抗体:

Cell Viability Assay[1]

Cell Line: H295R cells
Concentration: 0.2 mg/L, 2 mg/L
Incubation Time: 48 h
Result: Exposure to 0.2 mg/L and 2 mg/L Sulfathiazole for 48 h upregulated the mRNA expression of CYP17, CYP19, and 3βHSD2, which are key genes involved in the steroidogenic pathway.
体内研究
(In Vivo)

Sulfathiazole (50 mg/L、500 mg/L；水体暴露；每日喂食；14 d) 在雄性日本青鳉鱼 (Oryzias latipes) 模型中可显著提高血浆中 17-雌二醇 (E2) 浓度[1]。
Sulfathiazole (1%；混入纯化饲料；每日摄入) 在断奶期及断奶后不久的 Wistar 和 Osborne-Mendel 品系白化大鼠模型中导致骨髓中多形核中性粒细胞、杆状核细胞和晚幼粒细胞减少，骨骼肌坏死和钙化，肺/冠状动脉/肾动脉钙化或玻璃样变，肝细胞水样变性和局灶性透明坏死，肾上腺皮质细胞透明坏死，甲状腺增生，以及皮下组织、体腔和器官出血[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Japanese medaka (Oryzias latipes), 3-4 months old[1]
Dosage: 50 mg/L, 500 mg/L (water)
Administration: Waterborne exposure with ad libitum feeding of Artemia nauplii twice daily, renewed exposure medium at least three times per week for 14 d
Result: After 14-d exposure, plasma E2 concentrations in male medaka were significantly increased to 1.56 ng/mL (50 mg/L) and 2.06 ng/mL (500 mg/L), which were 1.32-fold and 1.75-fold higher than the control (1.18 ng/mL), respectively.
分子量

255.32

Formula

C9H9N3O2S2
CAS 号
性状

固体

颜色

White to off-white

中文名称

磺胺噻唑；磺胺塞唑
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 250 mg/mL (979.15 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.9166 mL 19.5830 mL 39.1659 mL
5 mM 0.7833 mL 3.9166 mL 7.8332 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.71%

COA (287 KB) HNMR (261 KB) LCMS (93 KB)

产品使用指南 (1538 KB)
参考文献

Sulfathiazole 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.9166 mL 19.5830 mL 39.1659 mL 97.9148 mL
5 mM 0.7833 mL 3.9166 mL 7.8332 mL 19.5830 mL
10 mM 0.3917 mL 1.9583 mL 3.9166 mL 9.7915 mL
15 mM 0.2611 mL 1.3055 mL 2.6111 mL 6.5277 mL
20 mM 0.1958 mL 0.9791 mL 1.9583 mL 4.8957 mL
25 mM 0.1567 mL 0.7833 mL 1.5666 mL 3.9166 mL
30 mM 0.1306 mL 0.6528 mL 1.3055 mL 3.2638 mL
40 mM 0.0979 mL 0.4896 mL 0.9791 mL 2.4479 mL
50 mM 0.0783 mL 0.3917 mL 0.7833 mL 1.9583 mL
60 mM 0.0653 mL 0.3264 mL 0.6528 mL 1.6319 mL
80 mM 0.0490 mL 0.2448 mL 0.4896 mL 1.2239 mL
100 mM 0.0392 mL 0.1958 mL 0.3917 mL 0.9791 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sulfathiazole72-14-0磺胺噻唑磺胺塞唑AntibioticBacterialsulfonamideantibioticbacteriaInhibitorinhibitorinhibit

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